Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation

Matti M. van Schooneveld; Esad Vucic; Rolf Koole; Yu Zhou; Joanne Stocks; David P. Cormode; Cheuk Y. Tang; Ronald E. Gordon; Klaas Nicolay; Andries Meijerink; Zahi A. Fayad; Willem J. M. Mulder

doi:https://doi.org/10.1021/nl801596a

Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation

Matti M. van Schooneveld, Esad Vucic, Rolf Koole, Yu Zhou, Joanne Stocks, David P. Cormode, Cheuk Y. Tang, Ronald E. Gordon, Klaas Nicolay, Andries Meijerink, Zahi A. Fayad, Willem J. M. Mulder

Medical Biochemistry (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

214 Citations (Scopus)

Abstract

Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics

Original language	English
Pages (from-to)	2517-2525
Journal	Nano letters
Volume	8
Issue number	8
DOIs	https://doi.org/10.1021/nl801596a
Publication status	Published - 2008

Access to Document

https://doi.org/10.1021/nl801596a

Cite this

van Schooneveld, M. M., Vucic, E., Koole, R., Zhou, Y., Stocks, J., Cormode, D. P., Tang, C. Y., Gordon, R. E., Nicolay, K., Meijerink, A., Fayad, Z. A., & Mulder, W. J. M. (2008). Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation. Nano letters, 8(8), 2517-2525. https://doi.org/10.1021/nl801596a

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abstract = "Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics",

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AU - van Schooneveld, Matti M.

AU - Vucic, Esad

AU - Koole, Rolf

AU - Zhou, Yu

AU - Stocks, Joanne

AU - Cormode, David P.

AU - Tang, Cheuk Y.

AU - Gordon, Ronald E.

AU - Nicolay, Klaas

AU - Meijerink, Andries

AU - Fayad, Zahi A.

AU - Mulder, Willem J. M.

PY - 2008

Y1 - 2008

N2 - Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics

AB - Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics

U2 - https://doi.org/10.1021/nl801596a

DO - https://doi.org/10.1021/nl801596a

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JO - Nano letters

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