Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

C. Strisciuglio; E. Scarpato; S. Cenni; M. R. Serra; F. P. Giugliano; C. G. Mainolfi; P. Dolce; M. Martinelli; A. Staiano; E. Miele

doi:https://doi.org/10.1016/j.dld.2020.03.004

Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

C. Strisciuglio, E. Scarpato, S. Cenni, M. R. Serra, F. P. Giugliano, C. G. Mainolfi, P. Dolce, M. Martinelli, A. Staiano, E. Miele

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Abstract

Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

Original language	English
Pages (from-to)	630-636
Number of pages	7
Journal	Digestive and liver disease
Volume	52
Issue number	6
Early online date	2020
DOIs	https://doi.org/10.1016/j.dld.2020.03.004
Publication status	Published - Jun 2020

Keywords

Bone mineralization
Crohn's disease
Exclusive enteral nutrition
Pediatrics

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https://doi.org/10.1016/j.dld.2020.03.004

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@article{c4d0426e7cb4428097ba73fb10ec09a0,

title = "Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease",

abstract = "Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.",

keywords = "Bone mineralization, Crohn's disease, Exclusive enteral nutrition, Pediatrics",

author = "C. Strisciuglio and E. Scarpato and S. Cenni and Serra, {M. R.} and Giugliano, {F. P.} and Mainolfi, {C. G.} and P. Dolce and M. Martinelli and A. Staiano and E. Miele",

note = "Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2020 Editrice Gastroenterologica Italiana S.r.l. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jun,

doi = "https://doi.org/10.1016/j.dld.2020.03.004",

language = "English",

volume = "52",

pages = "630--636",

journal = "Digestive and liver disease",

issn = "1590-8658",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

AU - Strisciuglio, C.

AU - Scarpato, E.

AU - Cenni, S.

AU - Serra, M. R.

AU - Giugliano, F. P.

AU - Mainolfi, C. G.

AU - Dolce, P.

AU - Martinelli, M.

AU - Staiano, A.

AU - Miele, E.

N1 - Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2020 Editrice Gastroenterologica Italiana S.r.l. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

AB - Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

KW - Bone mineralization

KW - Crohn's disease

KW - Exclusive enteral nutrition

KW - Pediatrics

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U2 - https://doi.org/10.1016/j.dld.2020.03.004

DO - https://doi.org/10.1016/j.dld.2020.03.004

M3 - Article

C2 - 32273172

SN - 1590-8658

VL - 52

SP - 630

EP - 636

JO - Digestive and liver disease

JF - Digestive and liver disease

IS - 6

ER -

Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

Abstract

Keywords

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