In-vitro differentiation of cells of patients with acute undifferentiated leukaemia

C. E. van der Schoot; F. J. Visser; P. A. Tetteroo; A. E. von dem Borne

In-vitro differentiation of cells of patients with acute undifferentiated leukaemia

C. E. van der Schoot, F. J. Visser, P. A. Tetteroo, A. E. von dem Borne

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

The diagnosis of acute undifferentiated leukaemia (AUL) is made when the cells of patients with acute leukaemias cannot be classified as myeloid or lymphoid by means of morphological, cytochemical and immunological criteria. The mononuclear cells of eight different AUL patients were cultured in suspension for 3 d with or without TPA. After culture, especially in the presence of TPA, the cells of all patients expressed at least one myeloid membrane antigen. It was shown that this antigen expression was dependent on de novo protein synthesis and not influenced by inhibition of proliferation

Original language	English
Pages (from-to)	351-355
Journal	British journal of haematology
Volume	71
Issue number	3
Publication status	Published - 1989

Cite this

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title = "In-vitro differentiation of cells of patients with acute undifferentiated leukaemia",

abstract = "The diagnosis of acute undifferentiated leukaemia (AUL) is made when the cells of patients with acute leukaemias cannot be classified as myeloid or lymphoid by means of morphological, cytochemical and immunological criteria. The mononuclear cells of eight different AUL patients were cultured in suspension for 3 d with or without TPA. After culture, especially in the presence of TPA, the cells of all patients expressed at least one myeloid membrane antigen. It was shown that this antigen expression was dependent on de novo protein synthesis and not influenced by inhibition of proliferation",

author = "{van der Schoot}, {C. E.} and Visser, {F. J.} and Tetteroo, {P. A.} and {von dem Borne}, {A. E.}",

year = "1989",

language = "English",

volume = "71",

pages = "351--355",

journal = "British journal of haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

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T1 - In-vitro differentiation of cells of patients with acute undifferentiated leukaemia

AU - van der Schoot, C. E.

AU - Visser, F. J.

AU - Tetteroo, P. A.

AU - von dem Borne, A. E.

PY - 1989

Y1 - 1989

N2 - The diagnosis of acute undifferentiated leukaemia (AUL) is made when the cells of patients with acute leukaemias cannot be classified as myeloid or lymphoid by means of morphological, cytochemical and immunological criteria. The mononuclear cells of eight different AUL patients were cultured in suspension for 3 d with or without TPA. After culture, especially in the presence of TPA, the cells of all patients expressed at least one myeloid membrane antigen. It was shown that this antigen expression was dependent on de novo protein synthesis and not influenced by inhibition of proliferation

AB - The diagnosis of acute undifferentiated leukaemia (AUL) is made when the cells of patients with acute leukaemias cannot be classified as myeloid or lymphoid by means of morphological, cytochemical and immunological criteria. The mononuclear cells of eight different AUL patients were cultured in suspension for 3 d with or without TPA. After culture, especially in the presence of TPA, the cells of all patients expressed at least one myeloid membrane antigen. It was shown that this antigen expression was dependent on de novo protein synthesis and not influenced by inhibition of proliferation

M3 - Article

C2 - 2649138

SN - 0007-1048

VL - 71

SP - 351

EP - 355

JO - British journal of haematology

JF - British journal of haematology

IS - 3

ER -