In vitro susceptibility of Helicobacter pylori to, and in vivo suppression by, antimicrobials used in selective decontamination of the digestive tract

P. H. van der Voort, R. W. van der Hulst, D. F. Zandstra, A. van der Ende, A. A. Geraedts, G. N. Tytgat

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The incidence of bleeding related to stress ulcers is reduced in critically ill patients in whom gut decontamination has been performed; this may be a result of suppression of Helicobacter pylori infection. We determined the susceptibility of H. pylori to the applied antibiotics. In nine of 10 critically ill patients (using intravenous cefotaxime and topical polymyxin, tobramycin and amphotericin B (PTA) given by nasogastric tube) and all six volunteers (using PTA alone), H. pylori was suppressed as long as the topical antibiotics were ingested. The in vitro studies revealed that all strains were susceptible to cefotaxime and tobramycin. The strains were not susceptible to polymyxin or amphotericin B
Original languageEnglish
Pages (from-to)803-805
JournalJournal of antimicrobial chemotherapy
Volume46
Issue number5
DOIs
Publication statusPublished - 2000

Cite this