TY - JOUR
T1 - In vivo imaging of TGFβ signalling components using positron emission tomography
AU - Rotteveel, Lonneke
AU - Poot, Alex J.
AU - Bogaard, Harm Jan
AU - ten Dijke, Peter
AU - Lammertsma, Adriaan A.
AU - Windhorst, Albert D.
PY - 2019/12
Y1 - 2019/12
N2 - The transforming growth factor β (TGFβ) family of cytokines achieves homeostasis through a careful balance and crosstalk with complex signalling pathways. Inappropriate activation or inhibition of this pathway and mutations in its components are related to diseases such as cancer, vascular diseases, and developmental disorders. Quantitative imaging of expression levels of key regulators within this pathway using positron emission tomography (PET) can provide insights into the role of this pathway in vivo, providing information on underlying pathophysiological processes. PET imaging can also be used to study the drug targeting of this pathway and to detect diseases in which this pathway is disturbed. In this review, we provide an overview of PET tracers available to study the TGFβ signalling pathway. In addition, we discuss future imaging targets for this pathway and possible leads for new PET tracers.
AB - The transforming growth factor β (TGFβ) family of cytokines achieves homeostasis through a careful balance and crosstalk with complex signalling pathways. Inappropriate activation or inhibition of this pathway and mutations in its components are related to diseases such as cancer, vascular diseases, and developmental disorders. Quantitative imaging of expression levels of key regulators within this pathway using positron emission tomography (PET) can provide insights into the role of this pathway in vivo, providing information on underlying pathophysiological processes. PET imaging can also be used to study the drug targeting of this pathway and to detect diseases in which this pathway is disturbed. In this review, we provide an overview of PET tracers available to study the TGFβ signalling pathway. In addition, we discuss future imaging targets for this pathway and possible leads for new PET tracers.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072274861&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31494189
U2 - https://doi.org/10.1016/j.drudis.2019.08.011
DO - https://doi.org/10.1016/j.drudis.2019.08.011
M3 - Review article
C2 - 31494189
SN - 1359-6446
VL - 24
SP - 2258
EP - 2272
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 12
ER -