TY - JOUR
T1 - Incidence of Sudden Cardiac Death in the European Union
AU - Empana, Jean-Philippe
AU - Lerner, Ivan
AU - Valentin, Eugenie
AU - Folke, Fredrik
AU - Böttiger, Bernd
AU - Gislason, Gunnar
AU - Jonsson, Martin
AU - Ringh, Mattias
AU - Beganton, Frankie
AU - Bougouin, Wulfran
AU - Marijon, Eloi
AU - Blom, Marieke
AU - ESCAPE-NET Investigators
AU - Tan, Hanno
AU - Jouven, Xavier
N1 - Funding Information: This work received funding from the European Union’s Horizon 2020 research and innovation program under the acronym ESCAPE-NET (grant agreement 733381) and the COST Action PARQ (grant agreement CA19137) supported by the European Cooperation in Science and Technology (COST). The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: © 2022 The Authors
PY - 2022/5/10
Y1 - 2022/5/10
N2 - Background: Although sudden cardiac death (SCD) is recognized as a high-priority public health topic, reliable estimates of the incidence of SCD or, more broadly, out-of-hospital cardiac arrest (OHCA), in the population are scarce, especially in the European Union. Objectives: The study objective was to determine the incidence of SCD and OHCA in the European Union. Methods: The study examined 4 large (ie, >2 million inhabitants) European population-based prospective registries collecting emergency medical services (EMS)–attended (ie, with attempted resuscitation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from January 2012 to December 2017 in the Paris region (France), the North Holland region (the Netherlands), the Stockholm region (Sweden), and in all of Denmark. Results: The average annual incidence of SCD in the 4 registries ranged from 36.8 per 100,000 (95% CI: 23.5-50.1 per 100,000) to 39.7 per 100,000 (95% CI: 32.6-46.8 per 100,000). When extrapolating to each European country and accounting for age and sex, this yields to 249,538 SCD cases per year (95% CI: 155,377-343,719 SCD cases per year). The average annual incidence of OHCA in the 4 registries ranged from 47.8 per 100,000 (95% CI: 21.2-74.4 per 100,000) to 57.9 per 100,000 (95% CI: 19.6-96.3 per 100,000), corresponding to 343,496 OHCA cases per year (95% CI: 216,472-464,922 OHCA cases per year) in the European Union. Incidence rates of SCD and OHCA increased with age and were systematically higher in men compared with women. Conclusions: By combining data from 4 large, population-based registries with at least 5 years of data collection, this study provided an estimate of the incidence of SCD and OHCA in the European Union.
AB - Background: Although sudden cardiac death (SCD) is recognized as a high-priority public health topic, reliable estimates of the incidence of SCD or, more broadly, out-of-hospital cardiac arrest (OHCA), in the population are scarce, especially in the European Union. Objectives: The study objective was to determine the incidence of SCD and OHCA in the European Union. Methods: The study examined 4 large (ie, >2 million inhabitants) European population-based prospective registries collecting emergency medical services (EMS)–attended (ie, with attempted resuscitation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from January 2012 to December 2017 in the Paris region (France), the North Holland region (the Netherlands), the Stockholm region (Sweden), and in all of Denmark. Results: The average annual incidence of SCD in the 4 registries ranged from 36.8 per 100,000 (95% CI: 23.5-50.1 per 100,000) to 39.7 per 100,000 (95% CI: 32.6-46.8 per 100,000). When extrapolating to each European country and accounting for age and sex, this yields to 249,538 SCD cases per year (95% CI: 155,377-343,719 SCD cases per year). The average annual incidence of OHCA in the 4 registries ranged from 47.8 per 100,000 (95% CI: 21.2-74.4 per 100,000) to 57.9 per 100,000 (95% CI: 19.6-96.3 per 100,000), corresponding to 343,496 OHCA cases per year (95% CI: 216,472-464,922 OHCA cases per year) in the European Union. Incidence rates of SCD and OHCA increased with age and were systematically higher in men compared with women. Conclusions: By combining data from 4 large, population-based registries with at least 5 years of data collection, this study provided an estimate of the incidence of SCD and OHCA in the European Union.
KW - cardiac arrest
KW - incidence rates
KW - registries
KW - sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=85129416614&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jacc.2022.02.041
DO - https://doi.org/10.1016/j.jacc.2022.02.041
M3 - Article
C2 - 35512862
SN - 0735-1097
VL - 79
SP - 1818
EP - 1827
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 18
ER -