Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

M. D. Hazenberg; S. A. Otto; J. W. Cohen Stuart; M. C. Verschuren; J. C. Borleffs; C. A. Boucher; R. A. Coutinho; J. M. Lange; T. F. Rinke de Wit; A. Tsegaye; J. J. van Dongen; D. Hamann; R. J. de Boer; F. Miedema

doi:https://doi.org/10.1038/79549

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

M. D. Hazenberg, S. A. Otto, J. W. Cohen Stuart, M. C. Verschuren, J. C. Borleffs, C. A. Boucher, R. A. Coutinho, J. M. Lange, T. F. Rinke de Wit, A. Tsegaye, J. J. van Dongen, D. Hamann, R. J. de Boer, F. Miedema

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Abstract

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation

Original language	English
Pages (from-to)	1036-1042
Journal	Nature medicine
Volume	6
Issue number	9
DOIs	https://doi.org/10.1038/79549
Publication status	Published - 2000

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Hazenberg, M. D., Otto, S. A., Cohen Stuart, J. W., Verschuren, M. C., Borleffs, J. C., Boucher, C. A., Coutinho, R. A., Lange, J. M., Rinke de Wit, T. F., Tsegaye, A., van Dongen, J. J., Hamann, D., de Boer, R. J., & Miedema, F. (2000). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nature medicine, 6(9), 1036-1042. https://doi.org/10.1038/79549

@article{f11d7c0463e2405c9f07634c4ff8cf5e,

title = "Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection",

abstract = "Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation",

author = "Hazenberg, {M. D.} and Otto, {S. A.} and {Cohen Stuart}, {J. W.} and Verschuren, {M. C.} and Borleffs, {J. C.} and Boucher, {C. A.} and Coutinho, {R. A.} and Lange, {J. M.} and {Rinke de Wit}, {T. F.} and A. Tsegaye and {van Dongen}, {J. J.} and D. Hamann and {de Boer}, {R. J.} and F. Miedema",

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Hazenberg, MD, Otto, SA, Cohen Stuart, JW, Verschuren, MC, Borleffs, JC, Boucher, CA, Coutinho, RA, Lange, JM, Rinke de Wit, TF, Tsegaye, A, van Dongen, JJ, Hamann, D, de Boer, RJ & Miedema, F 2000, 'Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection', Nature medicine, vol. 6, no. 9, pp. 1036-1042. https://doi.org/10.1038/79549

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T1 - Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

AU - Hazenberg, M. D.

AU - Otto, S. A.

AU - Cohen Stuart, J. W.

AU - Verschuren, M. C.

AU - Borleffs, J. C.

AU - Boucher, C. A.

AU - Coutinho, R. A.

AU - Lange, J. M.

AU - Rinke de Wit, T. F.

AU - Tsegaye, A.

AU - van Dongen, J. J.

AU - Hamann, D.

AU - de Boer, R. J.

AU - Miedema, F.

PY - 2000

Y1 - 2000

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AB - Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation

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DO - https://doi.org/10.1038/79549

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