Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis

Asrat Hailu; Jennie M. Pater; Piet A. Kager; Tom van der Poll

doi:https://doi.org/10.1080/00365540310017546

Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis

Asrat Hailu, Jennie M. Pater, Piet A. Kager, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes

Original language	English
Pages (from-to)	56-58
Journal	Scandinavian journal of infectious diseases
Volume	36
Issue number	1
DOIs	https://doi.org/10.1080/00365540310017546
Publication status	Published - 2004

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https://doi.org/10.1080/00365540310017546

Cite this

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title = "Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis",

abstract = "Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes",

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AU - van der Poll, Tom

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AB - Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes

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