TY - CHAP
T1 - Increased risk of diabetes due to obesity
T2 - Does chronodisruption play a role?
AU - La Fleur, Susanne E.
AU - Kalsbeek, Andries
N1 - Publisher Copyright: © Springer Science+Business Media New York 2013. All rights are reserved.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - The prevalence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic proportions. The pathophysiology of T2DM is complex and involves insulin resistance, pancreatic β-cell dysfunction and visceral adiposity. Although it has been known for quite some time that a disruption of biological rhythms (as happens with shift work) increases the risk of developing obesity, insulin resistance and T2DM, more recent genomic evidence has further spiked the interest for the involvement of circadian rhythms (and their disruption) in the development of diabetes. In this chapter, we will start with an overview of the way in which glucose metabolism and the basal rhythm in plasma glucose concentrations and insulin sensitivity are regulated, after which we will discuss how a disruption of daily rhythms or a disruption of clock elements, may contribute to the development of insulin resistance.
AB - The prevalence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic proportions. The pathophysiology of T2DM is complex and involves insulin resistance, pancreatic β-cell dysfunction and visceral adiposity. Although it has been known for quite some time that a disruption of biological rhythms (as happens with shift work) increases the risk of developing obesity, insulin resistance and T2DM, more recent genomic evidence has further spiked the interest for the involvement of circadian rhythms (and their disruption) in the development of diabetes. In this chapter, we will start with an overview of the way in which glucose metabolism and the basal rhythm in plasma glucose concentrations and insulin sensitivity are regulated, after which we will discuss how a disruption of daily rhythms or a disruption of clock elements, may contribute to the development of insulin resistance.
UR - http://www.scopus.com/inward/record.url?scp=84929563695&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-1-4614-5082-5_7
DO - https://doi.org/10.1007/978-1-4614-5082-5_7
M3 - Chapter
SN - 1461450810
SN - 9781461450818
SP - 111
EP - 131
BT - Chronobiology and Obesity
PB - Springer New York
ER -