Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

Dirk Eggink; Stijn P. Andeweg; Harry Vennema; Noortje van Maarseveen; Klaas Vermaas; Boris Vlaemynck; Raf Schepers; Arianne B. van Gageldonk-Lafeber; Susan van den Hof; Chantal B. E. M. Reusken; Mirjam J. Knol

doi:https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196

Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

Dirk Eggink, Stijn P. Andeweg, Harry Vennema, Noortje van Maarseveen, Klaas Vermaas, Boris Vlaemynck, Raf Schepers, Arianne B. van Gageldonk-Lafeber, Susan van den Hof, Chantal B. E. M. Reusken, Mirjam J. Knol

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARSCoV-2-infected individuals (≥12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.

Original language	English
Article number	2101196
Journal	Euro surveillance
Volume	27
Issue number	4
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196
Publication status	Published - 27 Jan 2022

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Eggink, D., Andeweg, S. P., Vennema, H., van Maarseveen, N., Vermaas, K., Vlaemynck, B., Schepers, R., van Gageldonk-Lafeber, A. B., van den Hof, S., Reusken, C. B. E. M., & Knol, M. J. (2022). Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022. Euro surveillance, 27(4), Article 2101196. https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196

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title = "Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022",

abstract = "Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARSCoV-2-infected individuals (≥12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected na{\"i}ve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.",

author = "Dirk Eggink and Andeweg, {Stijn P.} and Harry Vennema and {van Maarseveen}, Noortje and Klaas Vermaas and Boris Vlaemynck and Raf Schepers and {van Gageldonk-Lafeber}, {Arianne B.} and {van den Hof}, Susan and Reusken, {Chantal B. E. M.} and Knol, {Mirjam J.}",

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Eggink, D, Andeweg, SP, Vennema, H, van Maarseveen, N, Vermaas, K, Vlaemynck, B, Schepers, R, van Gageldonk-Lafeber, AB, van den Hof, S, Reusken, CBEM & Knol, MJ 2022, 'Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022', Euro surveillance, vol. 27, no. 4, 2101196. https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196

Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022. / Eggink, Dirk; Andeweg, Stijn P.; Vennema, Harry et al.
In: Euro surveillance, Vol. 27, No. 4, 2101196, 27.01.2022.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

AU - Eggink, Dirk

AU - Andeweg, Stijn P.

AU - Vennema, Harry

AU - van Maarseveen, Noortje

AU - Vermaas, Klaas

AU - Vlaemynck, Boris

AU - Schepers, Raf

AU - van Gageldonk-Lafeber, Arianne B.

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AU - Reusken, Chantal B. E. M.

AU - Knol, Mirjam J.

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AB - Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARSCoV-2-infected individuals (≥12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.

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Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

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