Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system

Beatrijs L. P. Bloemers, Chantal J. M. Broers, Louis Bont, Michel E. Weijerman, Reinoud J. B. J. Gemke, A. Marceline van Furth

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84 Citations (Scopus)


Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed
Original languageEnglish
Pages (from-to)799-808
JournalMicrobes and infection / Institut Pasteur
Issue number11
Publication statusPublished - 2010

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