Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosis

M. J. Van Tricht; D. H. Nieman; L. J. Bour; T. Boerée; J. H. T. M. Koelman; L. de Haan; D. H. Linszen

doi:https://doi.org/10.1016/j.bandc.2010.05.005

Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosis

M. J. Van Tricht, D. H. Nieman, L. J. Bour, T. Boerée, J. H. T. M. Koelman, L. de Haan, D. H. Linszen

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Abstract

Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR patients and twenty-eight age and education matched controls were assessed with a task of SPEM and psychiatric questionnaires. Our results showed that both the corrective and non-corrective saccadic rates during pursuit were higher in the UHR group. There were however no differences in smooth pursuit gain between the two groups. The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system. (C) 2010 Elsevier Inc. All rights reserved

Original language	English
Pages (from-to)	215-221
Journal	Brain and Cognition
Volume	73
Issue number	3
DOIs	https://doi.org/10.1016/j.bandc.2010.05.005
Publication status	Published - 2010

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https://doi.org/10.1016/j.bandc.2010.05.005

Cite this

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title = "Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosis",

abstract = "Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR patients and twenty-eight age and education matched controls were assessed with a task of SPEM and psychiatric questionnaires. Our results showed that both the corrective and non-corrective saccadic rates during pursuit were higher in the UHR group. There were however no differences in smooth pursuit gain between the two groups. The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system. (C) 2010 Elsevier Inc. All rights reserved",

author = "{Van Tricht}, {M. J.} and Nieman, {D. H.} and Bour, {L. J.} and T. Boer{\'e}e and Koelman, {J. H. T. M.} and {de Haan}, L. and Linszen, {D. H.}",

year = "2010",

doi = "https://doi.org/10.1016/j.bandc.2010.05.005",

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TY - JOUR

T1 - Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosis

AU - Van Tricht, M. J.

AU - Nieman, D. H.

AU - Bour, L. J.

AU - Boerée, T.

AU - Koelman, J. H. T. M.

AU - de Haan, L.

AU - Linszen, D. H.

PY - 2010

Y1 - 2010

N2 - Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR patients and twenty-eight age and education matched controls were assessed with a task of SPEM and psychiatric questionnaires. Our results showed that both the corrective and non-corrective saccadic rates during pursuit were higher in the UHR group. There were however no differences in smooth pursuit gain between the two groups. The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system. (C) 2010 Elsevier Inc. All rights reserved

AB - Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR patients and twenty-eight age and education matched controls were assessed with a task of SPEM and psychiatric questionnaires. Our results showed that both the corrective and non-corrective saccadic rates during pursuit were higher in the UHR group. There were however no differences in smooth pursuit gain between the two groups. The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system. (C) 2010 Elsevier Inc. All rights reserved

U2 - https://doi.org/10.1016/j.bandc.2010.05.005

DO - https://doi.org/10.1016/j.bandc.2010.05.005

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SN - 0278-2626

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