Individual differences in sensitivity to factors provoking reinstatement of cocaine-seeking behavior

Judith R Homberg, Halfdan S Raasø, Anton N M Schoffelmeer, Taco J de Vries

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Among cocaine addicts, there is a strong variation in response to relapse provoking factors like conditioned cues and renewed contact with the drug. Here we show that such large individual differences also exist in rats. Reinstatement of extinguished cocaine-seeking behavior was triggered by contingent presentation of a cocaine-conditioned cue or an amphetamine priming injection. We found no positive correlation between cue- and drug-controlled reinstatement of cocaine seeking. Rather, a slight, but significant negative correlation was observed, which was particularly evident in two subgroups of rats that responded highest following either amphetamine priming or cue presentation. A large middle group responded equally for both relapse provoking factors. Further, cocaine-seeking behavior during the first extinction session correlated positively with cue-induced reinstatement. In conclusion, the present findings indicate that the therapeutic efficacy of relapse prevention strategies may depend on individual sensitivity to distinct relapse provoking stimuli.

Original languageEnglish
Pages (from-to)157-61
Number of pages5
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 4 Jun 2004


  • Amphetamine
  • Analysis of Variance
  • Animals
  • Behavior, Addictive
  • Behavior, Animal
  • Central Nervous System Stimulants
  • Cocaine
  • Cocaine-Related Disorders
  • Comparative Study
  • Cues
  • Dopamine Uptake Inhibitors
  • Extinction, Psychological
  • Female
  • Individuality
  • Journal Article
  • Male
  • Rats
  • Rats, Wistar
  • Reinforcement (Psychology)
  • Reinforcement Schedule
  • Research Support, Non-U.S. Gov't
  • Self Administration

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