Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report

Chris P. Bleeker; Robbert C. Bremer; Dave A. Dongelmans; Robert T.M. Van Dongen; Ben J.P. Crul

doi:https://doi.org/10.1053/eujp.2000.0220

Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report

Chris P. Bleeker, Robbert C. Bremer, Dave A. Dongelmans, Robert T.M. Van Dongen, Ben J.P. Crul

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400μg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.

Original language	English
Pages (from-to)	325-329
Number of pages	5
Journal	European Journal of Pain
Volume	5
Issue number	3
DOIs	https://doi.org/10.1053/eujp.2000.0220
Publication status	Published - 2001

Keywords

Fentanyl
Neuropathic pain
Opioid tolerance
Side effects
Transdermal

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AU - Crul, Ben J.P.

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AB - Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400μg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.

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KW - Side effects

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Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report

Abstract

Keywords

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