TY - JOUR
T1 - Infections and endothelial cells
AU - Keller, Tymen T.
AU - Mairuhu, Albert T. A.
AU - de Kruif, Martijn D.
AU - Klein, Saskia K.
AU - Gerdes, Victor E. A.
AU - ten Cate, Hugo
AU - Brandjes, Dees P. M.
AU - Levi, Marcel
AU - van Gorp, Eric C. M.
PY - 2003
Y1 - 2003
N2 - Systemic infection by various pathogens interacts with the endothelium and may result in altered coagulation, vasculitis and atherosclerosis. Endothelium plays a role in the initiation and regulation of both coagulation and fibrinolysis. Exposure of endothelial cells may lead to rapid activation of coagulation via tissue factor (TF) expression and the loss of anticoagulant properties by impairment of antithrombin III, TF pathway inhibitor (TFPI) and the protein C system. Endothelial-derived plasminogen activator inhibitor (PAI) is essential for the regulation of fibrinolysis and impaired endothelial function leads to imbalance in fibrinolysis, resulting in a procoagulant state. The interaction between inflammation and coagulation, soluble adhesion molecules and circulation endothelial cells is important in the pathogenesis of an unbalanced haemostatic system. Rather than being a unidirectional relationship, the interaction between inflammation and coagulation appears to be significant. In the crosstalk, the endothelium is playing a pivotal role. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved
AB - Systemic infection by various pathogens interacts with the endothelium and may result in altered coagulation, vasculitis and atherosclerosis. Endothelium plays a role in the initiation and regulation of both coagulation and fibrinolysis. Exposure of endothelial cells may lead to rapid activation of coagulation via tissue factor (TF) expression and the loss of anticoagulant properties by impairment of antithrombin III, TF pathway inhibitor (TFPI) and the protein C system. Endothelial-derived plasminogen activator inhibitor (PAI) is essential for the regulation of fibrinolysis and impaired endothelial function leads to imbalance in fibrinolysis, resulting in a procoagulant state. The interaction between inflammation and coagulation, soluble adhesion molecules and circulation endothelial cells is important in the pathogenesis of an unbalanced haemostatic system. Rather than being a unidirectional relationship, the interaction between inflammation and coagulation appears to be significant. In the crosstalk, the endothelium is playing a pivotal role. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/S0008-6363(03)00354-7
DO - https://doi.org/10.1016/S0008-6363(03)00354-7
M3 - Review article
C2 - 14522405
SN - 0008-6363
VL - 60
SP - 40
EP - 48
JO - Cardiovascular research
JF - Cardiovascular research
IS - 1
ER -