TY - JOUR
T1 - Inflammation markers are associated with cardiovascular diseases risk in adolescents: the Young Hearts project 2000
T2 - the Young Hearts project 2000
AU - Wijnstok, N.J.
AU - Twisk, J.W.R.
AU - Young, I.S.
AU - Woodside, J.V.
AU - McFarlane, C.
AU - McEneny, J.
AU - Hoekstra, T.
AU - Murray, L.
AU - Boreham, C.A.G.
N1 - http:/www.ncbi.nlm.nih.gov/pmc/articles/
PY - 2010
Y1 - 2010
N2 - PURPOSE: The traditional approach for identifying subjects at risk from cardiovascular diseases (CVD) is to determine the extent of clustering of biological risk factors adjusted for lifestyle. Recently, markers of endothelial dysfunction and low grade inflammation, including high sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecules (sICAM), and soluble vascular adhesion molecules (sVCAM), have been included in the detection for high risk individuals. However, the relationship of these novel biomarkers with CVD risk in adolescents remains unclear. The purpose of this study, therefore, was to establish the association of hsCRP, sICAM, and sVCAM with CVD risk in an adolescent population.METHODS: Data from the Young Hearts 2000 cross-sectional cohort study, carried out in 1999-2001, were used. From a total of 2,017 male and female participants, 95 obese subjects were identified and matched according to age, sex, and cigarette smoking, with 95 overweight and 95 normal-weight adolescents. Clustered CVD risk was computed using a sum of Z-scores of biological risk factors. The relationship was described using multiple linear regression analyses.RESULTS: hsCRP, sICAM, and sVCAM showed significant associations with CVD risk. hsCRP and sICAM had a positive relation with CVD risk, whereas sVCAM showed an inverse relationship. In this study, lifestyle factors showed no relation with CVD risk.CONCLUSION: The results fit the hypothesized role of low grade inflammation and endothelial dysfunction in CVD risk in asymptomatic adolescents. The inverse relationship of VCAM, however, is hard to explain and indicates the complex mechanisms underlying CVD. Further research is needed to draw firm conclusions on the biomarkers used.
AB - PURPOSE: The traditional approach for identifying subjects at risk from cardiovascular diseases (CVD) is to determine the extent of clustering of biological risk factors adjusted for lifestyle. Recently, markers of endothelial dysfunction and low grade inflammation, including high sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecules (sICAM), and soluble vascular adhesion molecules (sVCAM), have been included in the detection for high risk individuals. However, the relationship of these novel biomarkers with CVD risk in adolescents remains unclear. The purpose of this study, therefore, was to establish the association of hsCRP, sICAM, and sVCAM with CVD risk in an adolescent population.METHODS: Data from the Young Hearts 2000 cross-sectional cohort study, carried out in 1999-2001, were used. From a total of 2,017 male and female participants, 95 obese subjects were identified and matched according to age, sex, and cigarette smoking, with 95 overweight and 95 normal-weight adolescents. Clustered CVD risk was computed using a sum of Z-scores of biological risk factors. The relationship was described using multiple linear regression analyses.RESULTS: hsCRP, sICAM, and sVCAM showed significant associations with CVD risk. hsCRP and sICAM had a positive relation with CVD risk, whereas sVCAM showed an inverse relationship. In this study, lifestyle factors showed no relation with CVD risk.CONCLUSION: The results fit the hypothesized role of low grade inflammation and endothelial dysfunction in CVD risk in asymptomatic adolescents. The inverse relationship of VCAM, however, is hard to explain and indicates the complex mechanisms underlying CVD. Further research is needed to draw firm conclusions on the biomarkers used.
KW - Adolescent
KW - Biomarkers
KW - Blood Pressure
KW - Body Mass Index
KW - C-Reactive Protein
KW - Cardiovascular Diseases
KW - Cell Adhesion Molecules
KW - Child
KW - Cholesterol
KW - Cohort Studies
KW - Endothelium, Vascular
KW - Female
KW - Humans
KW - Inflammation
KW - Journal Article
KW - Life Style
KW - Linear Models
KW - Male
KW - Research Support, Non-U.S. Gov't
KW - Risk Factors
KW - Triglycerides
KW - Vascular Diseases
U2 - https://doi.org/10.1016/j.jadohealth.2010.04.008
DO - https://doi.org/10.1016/j.jadohealth.2010.04.008
M3 - Article
C2 - 20864003
SN - 1054-139X
VL - 47
SP - 346
EP - 351
JO - Journal of adolescent health
JF - Journal of adolescent health
IS - 4
ER -
