TY - JOUR
T1 - Inflammatory markers in AD and MCI patients with different biomarker profiles
AU - Schuitemaker, A.
AU - Dik, M.G.
AU - Veerhuis, R.
AU - Scheltens, P.
AU - Schoonenboom, S.N.M.
AU - Hack, C.E.
AU - Blankenstein, M.A.
AU - Jonker, C.
N1 - J English Article Schuitemaker, A, Vrije Univ Amsterdam Med Ctr, Dept Neurol, Alzheimer Ctr, POB 7057, NL-1007 MB Amsterdam, Netherlands a.schuitemaker@vumc.nl 30 1 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA NEUROBIOL AGING NOV Discipline: Geriatrics & Gerontology; Neurosciences 501ID
PY - 2009
Y1 - 2009
N2 - Objective: The aim of this study was to demonstrate the involvement of the inflammatory proteins IL-6, ACT and CRP early in the pathology process of AD in patients with mild cognitive impairment (MCI) and AD. Methods: IL-6, ACT, CRP, Aβ42, phospho-tau (p-tau) and total tau concentrations in serum and CSF of 145 patients with probable AD and 67 patients with MCI were measured by sandwich ELISA. MCI patients were characterized as high- respectively low-risk MCI according to their Aβ42/tau risk profile. Results: CSF and serum CRP levels were significantly higher in MCI compared to AD patients after adjustment for age, ApoE ε4 genotype and cardiovascular diseases (p < 0.01). This difference remained present in patients with a low-risk biomarker profile for AD after adjustment for abovementioned covariates. CSF IL-6 levels were also significantly higher in MCI patients with a low-risk CSF profile. Conclusions: These findings suggest that inflammatory processes might be involved in early stages of AD, even before Aβ and tau changes are present in CSF of MCI patients. © 2008 Elsevier Inc. All rights reserved.
AB - Objective: The aim of this study was to demonstrate the involvement of the inflammatory proteins IL-6, ACT and CRP early in the pathology process of AD in patients with mild cognitive impairment (MCI) and AD. Methods: IL-6, ACT, CRP, Aβ42, phospho-tau (p-tau) and total tau concentrations in serum and CSF of 145 patients with probable AD and 67 patients with MCI were measured by sandwich ELISA. MCI patients were characterized as high- respectively low-risk MCI according to their Aβ42/tau risk profile. Results: CSF and serum CRP levels were significantly higher in MCI compared to AD patients after adjustment for age, ApoE ε4 genotype and cardiovascular diseases (p < 0.01). This difference remained present in patients with a low-risk biomarker profile for AD after adjustment for abovementioned covariates. CSF IL-6 levels were also significantly higher in MCI patients with a low-risk CSF profile. Conclusions: These findings suggest that inflammatory processes might be involved in early stages of AD, even before Aβ and tau changes are present in CSF of MCI patients. © 2008 Elsevier Inc. All rights reserved.
U2 - https://doi.org/10.1016/j.neurobiolaging.2008.01.014
DO - https://doi.org/10.1016/j.neurobiolaging.2008.01.014
M3 - Article
C2 - 18378357
SN - 0197-4580
VL - 30
SP - 1885
EP - 1889
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 11
ER -