Inhibition of neurotransmitter release and adenylate cyclase activity by opioids: Ontogeny of functional mu, delta and kappa receptors in rat brain

T. J. de Vries, F. Hogenboom, A. H. Mulder, N. M. Schoffelmeer

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Activation of μ receptors by DAGO resulted in inhibition of cortical noradrenaline release and striatal dopamine-sensitive adenylate cyclase (AC) activity as early as gestational day 17 (E17). The κ agonist U50,488 had already inhibited striatal dopamine release on E17. In contrast, functional δ receptors emerged postnatally, mediating inhibition of striatal acetylcholine release on postnatal day 7 (P7) and of AC activity on P14.

Original languageEnglish
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
Publication statusPublished - 1 Jan 1990
EventThe International Narcotics Research Conference -
Duration: 8 Jul 198913 Jul 1989


ConferenceThe International Narcotics Research Conference

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