TY - JOUR
T1 - Innate immunity in the nervous system
AU - Ramaglia, V.
AU - Baas, F.
PY - 2009
Y1 - 2009
N2 - The complement (C) system plays a central role in innate immunity and bridges innate and adaptive immune responses. A fine balance of C activation and regulation mediates the elimination of invading pathogens and the protection of the host from excessive C deposition on healthy tissues. If this delicate balance is disrupted, the C system may cause injury and contribute to the pathogenesis of various diseases, including neurodegenerative disorders and neuropathies. Here we review evidence indicating that C factors and regulators are locally synthesized in the nervous system and we discuss the evidence supporting the protective or detrimental role of C activation in health, injury, and disease of the nerve
AB - The complement (C) system plays a central role in innate immunity and bridges innate and adaptive immune responses. A fine balance of C activation and regulation mediates the elimination of invading pathogens and the protection of the host from excessive C deposition on healthy tissues. If this delicate balance is disrupted, the C system may cause injury and contribute to the pathogenesis of various diseases, including neurodegenerative disorders and neuropathies. Here we review evidence indicating that C factors and regulators are locally synthesized in the nervous system and we discuss the evidence supporting the protective or detrimental role of C activation in health, injury, and disease of the nerve
U2 - https://doi.org/10.1016/S0079-6123(09)17507-6
DO - https://doi.org/10.1016/S0079-6123(09)17507-6
M3 - Review article
C2 - 19660651
SN - 0079-6123
VL - 175
SP - 95
EP - 123
JO - Progress in brain research
JF - Progress in brain research
ER -