Ins and outs of LFA-1

M Lub, Y van Kooyk, C G Figdor

Research output: Contribution to journalReview articleAcademicpeer-review

245 Citations (Scopus)


Leukocyte function-associated molecule 1 (LFA-1) is an integrin that plays a major role in the immune system. Recent findings demonstrate that LFA-1 has a two-way signaling function, mediating cell adhesion and stimulating intracellular processes at the same time. Here, Marijke Lub, Yvette van Kooyk and Carl Figdor discuss the 'inside-out' and 'outside-in' signaling properties of LFA-1, as a prototype leukocyte integrin, in normal and malignant T cells. They integrate data into a model that highlights the role of the cytoskeleton in the regulation of LFA-1.

Original languageEnglish
Pages (from-to)479-83
Number of pages5
JournalImmunology today
Issue number10
Publication statusPublished - Oct 1995


  • Animals
  • Cell Adhesion
  • Humans
  • Lymphocyte Function-Associated Antigen-1/physiology

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