Abstract
OBJECTIVE: In addition to insulin's metabolic actions, insulin can dilate arterioles which increase blood flow to metabolically active tissues. This effect is blunted in insulin-resistant subjects. Insulin's effect on SVR, determined by resistance arterioles, has, however, rarely been examined directly. We determined the effects of both hyperinsulinemia and a mixed meal on SVR and its relationship with insulin sensitivity.
METHODS: Thirty-seven lean and obese women underwent a hyperinsulinemic-euglycemic clamp, and 24 obese volunteers underwent a mixed-meal test. SVR was assessed using CPP before and during hyperinsulinemia as well as before and 60 and 120 minutes after a meal.
RESULTS: SVR decreased significantly during hyperinsulinemia (-13%; p < 0.001) and after the meal (-11%; p < 0.001). Insulin decreased SVR more strongly in insulin-sensitive individuals (standardized β: -0.44; p = 0.01). In addition, SVR at 60 minutes after meal ingestion was inversely related to the Matsuda index (β: -0.39; p = 0.04) and the change in postprandial SVR was directly related to postprandial glycemia (β: 0.53; p < 0.01).
CONCLUSIONS: Hyperinsulinemia and meal ingestion decrease SVR, which is directly associated with metabolic insulin resistance. This suggests that resistance to insulin-induced vasodilatation contributes to regulation of vascular resistance.
Original language | English |
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Pages (from-to) | 62-8 |
Number of pages | 7 |
Journal | Microcirculation |
Volume | 23 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2016 |
Keywords
- Adolescent
- Adult
- Blood Flow Velocity
- Clinical Trial
- Eating
- Female
- Glucose Clamp Technique
- Humans
- Hyperinsulinism
- Insulin
- Insulin Resistance
- Journal Article
- Male
- Middle Aged
- Postprandial Period
- Research Support, Non-U.S. Gov't
- Vascular Resistance
- Vasodilation
- hypertension