TY - JOUR
T1 - Integrated genomic characterization of oesophageal carcinoma
AU - The Cancer Genome Atlas Research Network
AU - Kim, Jihun
AU - Bowlby, Reanne
AU - Mungall, Andrew J.
AU - Robertson, A. Gordon
AU - Odze, Robert D.
AU - Cherniack, Andrew D.
AU - Shih, Juliann
AU - Pedamallu, Chandra Sekhar
AU - Cibulskis, Carrie
AU - Dunford, Andrew
AU - Meier, Samuel R.
AU - Kim, Jaegil
AU - Raphael, J.
AU - Wu, Hsin Ta
AU - Wong, Alexandra M.
AU - Willis, Joseph E.
AU - Bass, Adam J.
AU - Derks, Sarah
AU - Garman, Katherine
AU - McCall, Shannon J.
AU - Wiznerowicz, MacIej
AU - Pantazi, Angeliki
AU - Parfenov, Michael
AU - Thorsson, Vésteinn
AU - Shmulevich, Ilya
AU - Dhankani, Varsha
AU - Miller, Michael
AU - Sakai, Ku Leuven Ryo
AU - Wang, Kenneth
AU - Schultz, Nikolaus
AU - Shen, Ronglai
AU - Arora, Arshi
AU - Weinhold, Nils
AU - Sánchez-Vega, Francisco
AU - Kelsen, David P.
AU - Zhang, Julia
AU - Felau, Ina
AU - Demchok, John
AU - Rabkin, Charles S.
AU - Camargo, M. Constanza
AU - Zenklusen, Jean Claude
AU - Bowen, Jay
AU - Leraas, Kristen
AU - Lichtenberg, Tara M.
AU - Curtis, Christina
AU - Seoane, Jose A.
AU - Ojesina, Akinyemi I.
AU - Beer, David G.
AU - Gulley, Margaret L.
AU - Pennathur, Arjun
PY - 2017/1/12
Y1 - 2017/1/12
N2 - Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
AB - Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
UR - http://www.scopus.com/inward/record.url?scp=85016278868&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/nature20805
DO - https://doi.org/10.1038/nature20805
M3 - Article
C2 - 28052061
SN - 0028-0836
VL - 541
SP - 169
EP - 174
JO - NATURE
JF - NATURE
IS - 7636
ER -