Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

P.J.G. Zwijnenburg; T. van der Poll; S Florquin; J.J. Roord; A.M. van Furth

doi:https://doi.org/10.1128/IAI.71.4.2276-2279.2003

Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

P.J.G. Zwijnenburg, T. van der Poll, S Florquin, J.J. Roord, A.M. van Furth

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced

Original language	English
Pages (from-to)	2276-9
Number of pages	4
Journal	Infection and immunity
Volume	71
Issue number	4
DOIs	https://doi.org/10.1128/IAI.71.4.2276-2279.2003
Publication status	Published - Apr 2003

Keywords

Animals
Blood/microbiology
Brain/immunology
Cerebrospinal Fluid/microbiology
Chemokines/metabolism
Cytokines/metabolism
Gene Expression Regulation
Interleukin-10/deficiency
Meningitis, Pneumococcal/immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Streptococcus pneumoniae/immunology

Access to Document

https://doi.org/10.1128/IAI.71.4.2276-2279.2003

https://research.vumc.nl/ws/files/10002958/PMC152042

Cite this

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title = "Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.",

abstract = "To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced",

keywords = "Animals, Blood/microbiology, Brain/immunology, Cerebrospinal Fluid/microbiology, Chemokines/metabolism, Cytokines/metabolism, Gene Expression Regulation, Interleukin-10/deficiency, Meningitis, Pneumococcal/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Streptococcus pneumoniae/immunology",

author = "P.J.G. Zwijnenburg and {van der Poll}, T. and S Florquin and J.J. Roord and {van Furth}, A.M.",

year = "2003",

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doi = "https://doi.org/10.1128/IAI.71.4.2276-2279.2003",

language = "English",

volume = "71",

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T1 - Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

AU - Zwijnenburg, P.J.G.

AU - van der Poll, T.

AU - Florquin, S

AU - Roord, J.J.

AU - van Furth, A.M.

PY - 2003/4

Y1 - 2003/4

N2 - To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced

AB - To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced

KW - Animals

KW - Blood/microbiology

KW - Brain/immunology

KW - Cerebrospinal Fluid/microbiology

KW - Chemokines/metabolism

KW - Cytokines/metabolism

KW - Gene Expression Regulation

KW - Interleukin-10/deficiency

KW - Meningitis, Pneumococcal/immunology

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Streptococcus pneumoniae/immunology

U2 - https://doi.org/10.1128/IAI.71.4.2276-2279.2003

DO - https://doi.org/10.1128/IAI.71.4.2276-2279.2003

M3 - Article

C2 - 12654856

SN - 0019-9567

VL - 71

SP - 2276

EP - 2279

JO - Infection and immunity

JF - Infection and immunity

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