Abstract
We investigated the role of CD25 as a prognostic marker in acute myeloid leukaemia (AML). Seventy-two newly diagnosed patients ≤60 years were retrospectively analysed by flow cytometry for CD25 positivity of AML blasts. Patients with CD25 expression of >10%, when compared to ≤10%, had a significantly shorter overall survival (OS, p = 0.0005) and relapse-free survival (RFS, p = 0.005). In multivariate analysis CD25 expression is an independent adverse factor for OS and RFS. High CD25 combined with FLT3-ITD positivity resulted in the poorest OS and RFS (p = 0.001 and p = 0.003, respectively). CD25 expression remained prognostic within the intermediate cytogenetic risk group. In addition, after the first cycle of chemotherapy, a significantly higher MRD frequency was found in patients expressing CD25 above cut-off (p = 0.003). Our results show that CD25 expression is an independent adverse prognostic marker in AML patients ≤60 and correlates with MRD. © 2009 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 1692-1699 |
Number of pages | 8 |
Journal | European Journal of Cancer |
Volume | 45 |
Issue number | 9 |
DOIs | |
Publication status | Published - Jun 2009 |
Keywords
- Acute myeloid leukaemia
- Flow cytometry
- IL-2 receptor
- Intermediate cytogenetics
- Prognosis