Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation

C. E. van der Schoot; P. Jansen; M. Poorter; M. R. Wester; A. E. von dem Borne; L. A. Aarden; R. H. van Oers

Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation

C. E. van der Schoot, P. Jansen, M. Poorter, M. R. Wester, A. E. von dem Borne, L. A. Aarden, R. H. van Oers

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Abstract

Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes

Original language	English
Pages (from-to)	2081-2087
Journal	Blood
Volume	74
Issue number	6
Publication status	Published - 1989

Cite this

@article{71c71670e6894c10b581382dd9936a4e,

title = "Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation",

abstract = "Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes",

author = "{van der Schoot}, {C. E.} and P. Jansen and M. Poorter and Wester, {M. R.} and {von dem Borne}, {A. E.} and Aarden, {L. A.} and {van Oers}, {R. H.}",

year = "1989",

language = "English",

volume = "74",

pages = "2081--2087",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "6",

}

TY - JOUR

T1 - Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation

AU - van der Schoot, C. E.

AU - Jansen, P.

AU - Poorter, M.

AU - Wester, M. R.

AU - von dem Borne, A. E.

AU - Aarden, L. A.

AU - van Oers, R. H.

PY - 1989

Y1 - 1989

N2 - Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes

AB - Several authors have reported the in vitro production of colony-stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes

M3 - Article

C2 - 2478222

SN - 0006-4971

VL - 74

SP - 2081

EP - 2087

JO - Blood

JF - Blood

IS - 6

ER -