TY - JOUR
T1 - Intermittent morphine treatment causes a protracted increase in cholinergic striatal neurotransmission measured ex vivo
AU - Schoffelmeer, Anton N.M.
AU - Nestby, Patrizia
AU - Tjon, Guno H.K.
AU - Wardeh, George
AU - De Vries, Taco J.
AU - Vanderschuren, Louk J.M.J.
AU - Mulder, Arie H.
PY - 1995/11/24
Y1 - 1995/11/24
N2 - Considering the long-lasting neuroadaptations that occur in the brain after exposure to drugs of abuse, we found that the facilitatory effect of an EC50 concentration (0.1 μM) of the acetylcholinesterase inhibitor physostigmine, unlike that of the muscarinic receptor agonist oxotremorine, on K+-induced [3H]dopamine release from rat striatal slices was enhanced about 2-fold 1 month after cessation of intermittent morphine treatment. Similarly, the inhibitory effect of physostigmine on K+-induced [14C]acetylcholine release from the slices was enhanced subsequent to morphine treatment, whereas that of oxotremorine appeared to be unchanged. Therefore, intermittent morphine administration may cause a very long-lasting increase of muscarinic receptor activation by released endogenous acetylcholine in rat striatum, which may play a pivotal role in the enduring character of stimulus hyperresponsiveness after exposure to drugs of abuse.
AB - Considering the long-lasting neuroadaptations that occur in the brain after exposure to drugs of abuse, we found that the facilitatory effect of an EC50 concentration (0.1 μM) of the acetylcholinesterase inhibitor physostigmine, unlike that of the muscarinic receptor agonist oxotremorine, on K+-induced [3H]dopamine release from rat striatal slices was enhanced about 2-fold 1 month after cessation of intermittent morphine treatment. Similarly, the inhibitory effect of physostigmine on K+-induced [14C]acetylcholine release from the slices was enhanced subsequent to morphine treatment, whereas that of oxotremorine appeared to be unchanged. Therefore, intermittent morphine administration may cause a very long-lasting increase of muscarinic receptor activation by released endogenous acetylcholine in rat striatum, which may play a pivotal role in the enduring character of stimulus hyperresponsiveness after exposure to drugs of abuse.
KW - Acetylcholine
KW - Morphine
KW - Muscarinic receptor
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=0028874548&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/0014-2999(95)00588-7
DO - https://doi.org/10.1016/0014-2999(95)00588-7
M3 - Article
C2 - 8608794
SN - 0014-2999
VL - 286
SP - 311
EP - 314
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 3
ER -