International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

Marek Jutel; Ioana Agache; Sergio Bonini; A. Wesley Burks; Moises Calderon; Walter Canonica; Linda Cox; Pascal Demoly; Antony J. Frew; Robyn O'Hehir; Jörg Kleine-Tebbe; Antonella Muraro; Gideon Lack; Désirée Larenas; Michael Levin; Bryan L. Martin; Harald Nelson; Ruby Pawankar; Oliver Pfaar; Ronald van Ree; Hugh Sampson; James L. Sublett; Kazunari Sugita; George Du Toit; Thomas Werfel; Roy Gerth van Wijk; Luo Zhang; Mübeccel Akdis; Cezmi A. Akdis

doi:https://doi.org/10.1016/j.jaci.2015.12.1300

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

Marek Jutel, Ioana Agache, Sergio Bonini, A. Wesley Burks, Moises Calderon, Walter Canonica, Linda Cox, Pascal Demoly, Antony J. Frew, Robyn O'Hehir, Jörg Kleine-Tebbe, Antonella Muraro, Gideon Lack, Désirée Larenas, Michael Levin, Bryan L. Martin, Harald Nelson, Ruby Pawankar, Oliver Pfaar, Ronald van ReeHugh Sampson, James L. Sublett, Kazunari Sugita, George Du Toit, Thomas Werfel, Roy Gerth van Wijk, Luo Zhang, Mübeccel Akdis, Cezmi A. Akdis

Research output: Contribution to journal › Article › Academic › peer-review

193 Citations (Scopus)

Abstract

This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein

Original language	English
Pages (from-to)	358-368
Journal	Journal of allergy and clinical immunology
Volume	137
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2015.12.1300
Publication status	Published - 2016

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https://doi.org/10.1016/j.jaci.2015.12.1300

Cite this

Jutel, M., Agache, I., Bonini, S., Burks, A. W., Calderon, M., Canonica, W., Cox, L., Demoly, P., Frew, A. J., O'Hehir, R., Kleine-Tebbe, J., Muraro, A., Lack, G., Larenas, D., Levin, M., Martin, B. L., Nelson, H., Pawankar, R., Pfaar, O., ... Akdis, C. A. (2016). International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics. Journal of allergy and clinical immunology, 137(2), 358-368. https://doi.org/10.1016/j.jaci.2015.12.1300

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title = "International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics",

abstract = "This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein",

author = "Marek Jutel and Ioana Agache and Sergio Bonini and Burks, {A. Wesley} and Moises Calderon and Walter Canonica and Linda Cox and Pascal Demoly and Frew, {Antony J.} and Robyn O'Hehir and J{\"o}rg Kleine-Tebbe and Antonella Muraro and Gideon Lack and D{\'e}sir{\'e}e Larenas and Michael Levin and Martin, {Bryan L.} and Harald Nelson and Ruby Pawankar and Oliver Pfaar and {van Ree}, Ronald and Hugh Sampson and Sublett, {James L.} and Kazunari Sugita and {Du Toit}, George and Thomas Werfel and {Gerth van Wijk}, Roy and Luo Zhang and M{\"u}beccel Akdis and Akdis, {Cezmi A.}",

year = "2016",

doi = "https://doi.org/10.1016/j.jaci.2015.12.1300",

language = "English",

volume = "137",

pages = "358--368",

journal = "Journal of allergy and clinical immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

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Jutel, M, Agache, I, Bonini, S, Burks, AW, Calderon, M, Canonica, W, Cox, L, Demoly, P, Frew, AJ, O'Hehir, R, Kleine-Tebbe, J, Muraro, A, Lack, G, Larenas, D, Levin, M, Martin, BL, Nelson, H, Pawankar, R, Pfaar, O, van Ree, R, Sampson, H, Sublett, JL, Sugita, K, Du Toit, G, Werfel, T, Gerth van Wijk, R, Zhang, L, Akdis, M & Akdis, CA 2016, 'International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics', Journal of allergy and clinical immunology, vol. 137, no. 2, pp. 358-368. https://doi.org/10.1016/j.jaci.2015.12.1300

TY - JOUR

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AU - Jutel, Marek

AU - Agache, Ioana

AU - Bonini, Sergio

AU - Burks, A. Wesley

AU - Calderon, Moises

AU - Canonica, Walter

AU - Cox, Linda

AU - Demoly, Pascal

AU - Frew, Antony J.

AU - O'Hehir, Robyn

AU - Kleine-Tebbe, Jörg

AU - Muraro, Antonella

AU - Lack, Gideon

AU - Larenas, Désirée

AU - Levin, Michael

AU - Martin, Bryan L.

AU - Nelson, Harald

AU - Pawankar, Ruby

AU - Pfaar, Oliver

AU - van Ree, Ronald

AU - Sampson, Hugh

AU - Sublett, James L.

AU - Sugita, Kazunari

AU - Du Toit, George

AU - Werfel, Thomas

AU - Gerth van Wijk, Roy

AU - Zhang, Luo

AU - Akdis, Mübeccel

AU - Akdis, Cezmi A.

PY - 2016

Y1 - 2016

N2 - This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein

AB - This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein

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DO - https://doi.org/10.1016/j.jaci.2015.12.1300

M3 - Article

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SN - 0091-6749

VL - 137

SP - 358

EP - 368

JO - Journal of allergy and clinical immunology

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ER -