Interobserver variation in histopathological grading of cervical dysplasia

Henrica C.W. de Vet; Paul G. Knipschild; Hubert J.A. Schouten; Johan Koudstaal; Wie Seen Kwee; Dirk Willebrand; Ferd Sturmans; Jan Willem Arends

doi:https://doi.org/10.1016/0895-4356(90)90107-Z

Interobserver variation in histopathological grading of cervical dysplasia

Henrica C.W. de Vet, Paul G. Knipschild, Hubert J.A. Schouten, Johan Koudstaal, Wie Seen Kwee, Dirk Willebrand, Ferd Sturmans, Jan Willem Arends

CCA - Treatment and quality of life (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In order to assess the variability among histopathologists in grading cervical dysplasia, four experienced histopathologists examined the same set of 106 biopsy specimens and assigned them to one of five diagnostic categories. These were: no dysplasia, mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma in situ. The histopathologists did not discuss the grading criteria beforehand. There was considerable disagreement among the pathologists: unweighted group κ 0.28, weighted group κ 0.56. It appeared that all grades of dysplasia were equally difficult to distinguish from adjacent categories. Various explanations for this interobserver variation are put forward.

Original language	English
Pages (from-to)	1395-1398
Number of pages	4
Journal	Journal of Clinical Epidemiology
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/0895-4356(90)90107-Z
Publication status	Published - 1 Jan 1990

Keywords

Cervix dysplasia
Concordance
Histology

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title = "Interobserver variation in histopathological grading of cervical dysplasia",

abstract = "In order to assess the variability among histopathologists in grading cervical dysplasia, four experienced histopathologists examined the same set of 106 biopsy specimens and assigned them to one of five diagnostic categories. These were: no dysplasia, mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma in situ. The histopathologists did not discuss the grading criteria beforehand. There was considerable disagreement among the pathologists: unweighted group κ 0.28, weighted group κ 0.56. It appeared that all grades of dysplasia were equally difficult to distinguish from adjacent categories. Various explanations for this interobserver variation are put forward.",

keywords = "Cervix dysplasia, Concordance, Histology",

author = "{de Vet}, {Henrica C.W.} and Knipschild, {Paul G.} and Schouten, {Hubert J.A.} and Johan Koudstaal and Kwee, {Wie Seen} and Dirk Willebrand and Ferd Sturmans and Arends, {Jan Willem}",

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T1 - Interobserver variation in histopathological grading of cervical dysplasia

AU - de Vet, Henrica C.W.

AU - Knipschild, Paul G.

AU - Schouten, Hubert J.A.

AU - Koudstaal, Johan

AU - Kwee, Wie Seen

AU - Willebrand, Dirk

AU - Sturmans, Ferd

AU - Arends, Jan Willem

PY - 1990/1/1

Y1 - 1990/1/1

N2 - In order to assess the variability among histopathologists in grading cervical dysplasia, four experienced histopathologists examined the same set of 106 biopsy specimens and assigned them to one of five diagnostic categories. These were: no dysplasia, mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma in situ. The histopathologists did not discuss the grading criteria beforehand. There was considerable disagreement among the pathologists: unweighted group κ 0.28, weighted group κ 0.56. It appeared that all grades of dysplasia were equally difficult to distinguish from adjacent categories. Various explanations for this interobserver variation are put forward.

AB - In order to assess the variability among histopathologists in grading cervical dysplasia, four experienced histopathologists examined the same set of 106 biopsy specimens and assigned them to one of five diagnostic categories. These were: no dysplasia, mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma in situ. The histopathologists did not discuss the grading criteria beforehand. There was considerable disagreement among the pathologists: unweighted group κ 0.28, weighted group κ 0.56. It appeared that all grades of dysplasia were equally difficult to distinguish from adjacent categories. Various explanations for this interobserver variation are put forward.

KW - Cervix dysplasia

KW - Concordance

KW - Histology

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U2 - https://doi.org/10.1016/0895-4356(90)90107-Z

DO - https://doi.org/10.1016/0895-4356(90)90107-Z

M3 - Article

C2 - 2254777

SN - 0895-4356

VL - 43

SP - 1395

EP - 1398

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

IS - 12

ER -

Interobserver variation in histopathological grading of cervical dysplasia

Abstract

Keywords

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