TY - JOUR
T1 - Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: The effect of electrosurgery on tissue discrimination using ex vivo animal tissue models
AU - Amiri, Sara Azizian
AU - van Gent, Carlijn M.
AU - Dankelman, Jenny
AU - Hendriks, Benno H. W.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Characterization of the formed debris on the optical fibers after electrosurgery revealed that the contamination is mostly burned tissue. Even with contaminated optical fibers, both tissues could still be discriminated with DRS based on fat/water ratio. Therefore, an electrosurgical knife integrated with DRS may be a promising technology to provide the surgeon with real-time guidance during BCS.
AB - Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Characterization of the formed debris on the optical fibers after electrosurgery revealed that the contamination is mostly burned tissue. Even with contaminated optical fibers, both tissues could still be discriminated with DRS based on fat/water ratio. Therefore, an electrosurgical knife integrated with DRS may be a promising technology to provide the surgeon with real-time guidance during BCS.
UR - http://www.scopus.com/inward/record.url?scp=85084650649&partnerID=8YFLogxK
U2 - https://doi.org/10.1364/BOE.385621
DO - https://doi.org/10.1364/BOE.385621
M3 - Article
C2 - 32499933
SN - 2156-7085
VL - 11
SP - 2402
EP - 2415
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 5
ER -