TY - JOUR
T1 - Invariant NKT cells in adrenoleukodystrophy patients and mice
AU - Gautron, A. S.
AU - Giquel, B.
AU - Beaudoin, L.
AU - Autrusseau, E.
AU - Speak, A.
AU - Platt, F.
AU - Kemp, S.
AU - Pujol, A.
AU - Aubourg, P.
AU - Lehuen, A.
PY - 2010
Y1 - 2010
N2 - X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizing glycolipid antigens through CD1d molecules, exert immunoregulatory functions and can prevent various immune mediated-pathologies. In ALD patients, but not in ALD deficient mice, iNKT cell frequency and CD1d expression on the surface of B cells are slightly decreased. However, such minor differences might not influence the pathogenesis of the disease. 0 2010 Elsevier B.V. All rights reserved
AB - X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizing glycolipid antigens through CD1d molecules, exert immunoregulatory functions and can prevent various immune mediated-pathologies. In ALD patients, but not in ALD deficient mice, iNKT cell frequency and CD1d expression on the surface of B cells are slightly decreased. However, such minor differences might not influence the pathogenesis of the disease. 0 2010 Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/j.jneuroim.2010.09.003
DO - https://doi.org/10.1016/j.jneuroim.2010.09.003
M3 - Article
C2 - 20920830
SN - 0165-5728
VL - 229
SP - 204
EP - 211
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -