Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging

Peter A. Jarzyna; Torjus Skajaa; Anita Gianella; David P. Cormode; Daniel D. Samber; Stephen D. Dickson; Wei Chen; Arjan W. Griffioen; Zahi A. Fayad; Willem J. M. Mulder

doi:https://doi.org/10.1016/j.biomaterials.2009.09.004

Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging

Peter A. Jarzyna, Torjus Skajaa, Anita Gianella, David P. Cormode, Daniel D. Samber, Stephen D. Dickson, Wei Chen, Arjan W. Griffioen, Zahi A. Fayad, Willem J. M. Mulder

Research output: Contribution to journal › Article › Academic › peer-review

103 Citations (Scopus)

Abstract

Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo

Original language	English
Pages (from-to)	6947-6954
Journal	Biomaterials
Volume	30
Issue number	36
DOIs	https://doi.org/10.1016/j.biomaterials.2009.09.004
Publication status	Published - 2009

Access to Document

https://doi.org/10.1016/j.biomaterials.2009.09.004

Cite this

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title = "Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging",

abstract = "Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo",

author = "Jarzyna, {Peter A.} and Torjus Skajaa and Anita Gianella and Cormode, {David P.} and Samber, {Daniel D.} and Dickson, {Stephen D.} and Wei Chen and Griffioen, {Arjan W.} and Fayad, {Zahi A.} and Mulder, {Willem J. M.}",

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T1 - Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging

AU - Jarzyna, Peter A.

AU - Skajaa, Torjus

AU - Gianella, Anita

AU - Cormode, David P.

AU - Samber, Daniel D.

AU - Dickson, Stephen D.

AU - Chen, Wei

AU - Griffioen, Arjan W.

AU - Fayad, Zahi A.

AU - Mulder, Willem J. M.

PY - 2009

Y1 - 2009

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AB - Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo

U2 - https://doi.org/10.1016/j.biomaterials.2009.09.004

DO - https://doi.org/10.1016/j.biomaterials.2009.09.004

M3 - Article

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