TY - JOUR
T1 - Is meniscal status in the anterior cruciate ligament injured knee associated with change in bone surface area? An exploratory analysis of the KANON trial
AU - Snoeker, B. A. M.
AU - Bowes, M. A.
AU - Roemer, F. W.
AU - Turkiewicz, A.
AU - Lohmander, L. S.
AU - Frobell, R. B.
AU - Englund, M.
N1 - Funding Information: Competing interests and funding: The KANON study and this project received funding from The Swedish Research Council , Greta and Johan Kock Foundations, the Medical Faculty of Lund University , Region Skåne, Governmental funding of clinical research within the national health services ( ALF ), The Swedish Rheumatism Association , Thelma Zoegas Fund, The Stig & Ragna Gorthon Research Foundation , Swedish National Centre for Research in Sports, Crafoord Foundation, Tore Nilsson Research Fund, and Pfizer Global Research. Funding sources had no role in the design, collection, and interpretation of the data or the decision to submit for publication.Dr. Roemer, one of the co-authors, is Chief Medical Officer and shareholder of BICL, LLC. Dr. Bowes is a senior director of clinical applications at IMorphics limited. Dr. Turkiewicz reports personal fees from Osteoarthritis and Cartilage, outside the submitted work. Dr. Englund reports receiving honorarium by Pfizer for being member of a 1-day advisory board (Tanezumab). Funding Information: Competing interests and funding: The KANON study and this project received funding from The Swedish Research Council, Greta and Johan Kock Foundations, the Medical Faculty of Lund University, Region Sk?ne, Governmental funding of clinical research within the national health services (ALF), The Swedish Rheumatism Association, Thelma Zoegas Fund, The Stig & Ragna Gorthon Research Foundation, Swedish National Centre for Research in Sports, Crafoord Foundation, Tore Nilsson Research Fund, and Pfizer Global Research. Funding sources had no role in the design, collection, and interpretation of the data or the decision to submit for publication.Dr. Roemer, one of the co-authors, is Chief Medical Officer and shareholder of BICL, LLC. Dr. Bowes is a senior director of clinical applications at IMorphics limited. Dr. Turkiewicz reports personal fees from Osteoarthritis and Cartilage, outside the submitted work. Dr. Englund reports receiving honorarium by Pfizer for being member of a 1-day advisory board (Tanezumab). Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Objectives: To study bone shape changes as a potential early feature of post-traumatic structural knee OA development, we estimated the association between meniscal status in the anterior cruciate ligament (ACL) injured knee and longitudinal condyle changes in bone surface area. Design: We used data from the KANON trial, including 121 young ACL-injured adults. We obtained baseline and 2-year follow-up knee MRIs. Our outcome was change in the bone surface areas (mean mm2, log-transformed) in 4 locations (femur, tibia, patella, and trochlea femur) in the medial and lateral compartment from baseline to 2 years. Meniscal pathology was defined as both present at baseline and newly developed (i.e., incident or progressed) using ACLOAS. We used multilevel linear regression adjusted for baseline bone area, age, sex, body mass index, treatment arm (i.e., early or optional delayed ACL reconstruction), and location. We analyzed medial and lateral compartment separately. We present results as percentage (%) bone area change difference with 95% confidence intervals (CI). Results: We analyzed 109 subjects (median 27 (18–36) years, 83% men) due to missing MRI information. The bone surface area increased on average by ∼2% over 2 years. The differences between knees with and without baseline meniscal pathology were 1.1% (95%CI 0.0–2.3%) and 1.4% (95%CI 0.6–2.2%) in the medial and lateral compartment, respectively, and 1.2% (95%CI 0.3–2.0%) and 1.3% (95%CI 0.6–2.0%) for medial and lateral newly developed pathology, respectively. Conclusion: Our finding of ∼1% increase bone area in compartment with meniscal pathology suggests a potentially important association between meniscal integrity and early bone surface area changes after ACL injury. Trial registration number ISRCTN 84752559.
AB - Objectives: To study bone shape changes as a potential early feature of post-traumatic structural knee OA development, we estimated the association between meniscal status in the anterior cruciate ligament (ACL) injured knee and longitudinal condyle changes in bone surface area. Design: We used data from the KANON trial, including 121 young ACL-injured adults. We obtained baseline and 2-year follow-up knee MRIs. Our outcome was change in the bone surface areas (mean mm2, log-transformed) in 4 locations (femur, tibia, patella, and trochlea femur) in the medial and lateral compartment from baseline to 2 years. Meniscal pathology was defined as both present at baseline and newly developed (i.e., incident or progressed) using ACLOAS. We used multilevel linear regression adjusted for baseline bone area, age, sex, body mass index, treatment arm (i.e., early or optional delayed ACL reconstruction), and location. We analyzed medial and lateral compartment separately. We present results as percentage (%) bone area change difference with 95% confidence intervals (CI). Results: We analyzed 109 subjects (median 27 (18–36) years, 83% men) due to missing MRI information. The bone surface area increased on average by ∼2% over 2 years. The differences between knees with and without baseline meniscal pathology were 1.1% (95%CI 0.0–2.3%) and 1.4% (95%CI 0.6–2.2%) in the medial and lateral compartment, respectively, and 1.2% (95%CI 0.3–2.0%) and 1.3% (95%CI 0.6–2.0%) for medial and lateral newly developed pathology, respectively. Conclusion: Our finding of ∼1% increase bone area in compartment with meniscal pathology suggests a potentially important association between meniscal integrity and early bone surface area changes after ACL injury. Trial registration number ISRCTN 84752559.
KW - Anterior cruciate ligament
KW - Bone surface area changes
KW - Meniscus
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=85103028505&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.joca.2021.02.567
DO - https://doi.org/10.1016/j.joca.2021.02.567
M3 - Article
C2 - 33676015
SN - 1063-4584
VL - 29
SP - 841
EP - 848
JO - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
JF - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
IS - 6
ER -