TY - JOUR
T1 - Is the relationship between early-onset cannabis use and educational attainment causal or due to common liability
AU - Verweij, K.J.H.
AU - Huizink, A.C.
AU - Agrawal, A.
AU - Martin, N.G.
AU - Lynskey, M.T.
PY - 2013
Y1 - 2013
N2 - Background: Several studies have shown that early cannabis use is correlated with poor educational performance including high school drop-out. The predominant explanation for this relationship is that cannabis use causes disengagement from education. Another explanation is that the association between early cannabis use and educational attainment is not causal, but the result of overlapping risk factors that increase the likelihood of both early cannabis use and disengagement from education. These confounding factors could be of genetic and/or environmental origin. Methods: Here we use data from a large community-based sample of adult twins (N= 3337) who completed a comprehensive semi-structured telephone interview. We first apply the classical twin-design to determine whether genetic and/or environmental influences underlie the relationship between early-onset cannabis use (prior to age 18) and early school leaving. Next, with a co-twin control design we investigate whether the relationship between the two variables is more likely due to direct causality or overlapping risk factors. Results: We find a significant phenotypic correlation between early-onset cannabis use and early school leaving (r= 0.26), which could be explained by familial influences (of genetic and/or shared environmental origin). The pattern of odds ratios found in the co-twin control design is not consistent with direct causation, but rather suggests that the association is due to shared environmental factors influencing both variables. Conclusion: Our findings suggest that the relationship between early-onset cannabis use and school leaving is due to shared environmental risk factors influencing both the risk of early-onset cannabis use and early school leaving. © 2013 Elsevier Ireland Ltd.
AB - Background: Several studies have shown that early cannabis use is correlated with poor educational performance including high school drop-out. The predominant explanation for this relationship is that cannabis use causes disengagement from education. Another explanation is that the association between early cannabis use and educational attainment is not causal, but the result of overlapping risk factors that increase the likelihood of both early cannabis use and disengagement from education. These confounding factors could be of genetic and/or environmental origin. Methods: Here we use data from a large community-based sample of adult twins (N= 3337) who completed a comprehensive semi-structured telephone interview. We first apply the classical twin-design to determine whether genetic and/or environmental influences underlie the relationship between early-onset cannabis use (prior to age 18) and early school leaving. Next, with a co-twin control design we investigate whether the relationship between the two variables is more likely due to direct causality or overlapping risk factors. Results: We find a significant phenotypic correlation between early-onset cannabis use and early school leaving (r= 0.26), which could be explained by familial influences (of genetic and/or shared environmental origin). The pattern of odds ratios found in the co-twin control design is not consistent with direct causation, but rather suggests that the association is due to shared environmental factors influencing both variables. Conclusion: Our findings suggest that the relationship between early-onset cannabis use and school leaving is due to shared environmental risk factors influencing both the risk of early-onset cannabis use and early school leaving. © 2013 Elsevier Ireland Ltd.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887025724&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/23972999
U2 - https://doi.org/10.1016/j.drugalcdep.2013.07.034
DO - https://doi.org/10.1016/j.drugalcdep.2013.07.034
M3 - Article
C2 - 23972999
SN - 0376-8716
VL - 133
SP - 580
EP - 586
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 2
ER -