Ischaemia with no obstructive coronary arteries

R. E. Konst; J. G. Meeder; M. E. Wittekoek; A. H.E.M. Maas; Y. Appelman; J. J. Piek; T. P. van de Hoef; P. Damman; S. E. Elias-Smale

doi:https://doi.org/10.1007/s12471-020-01451-9

Ischaemia with no obstructive coronary arteries

R. E. Konst, J. G. Meeder, M. E. Wittekoek, A. H.E.M. Maas, Y. Appelman, J. J. Piek, T. P. van de Hoef, P. Damman, S. E. Elias-Smale

Research output: Contribution to journal › Review article › Academic › peer-review

20 Citations (Scopus)

Abstract

Ischaemia with no obstructive coronary arteries (INOCA) is a common ischaemic heart disease with a female preponderance, mostly due to underlying coronary vascular dysfunction comprising coronary microvascular dysfunction and/or epicardial coronary vasospasm. Since standard ischaemia detection tests and coronary angiograms are not suitable to diagnose coronary vascular dysfunction, INOCA is often overlooked in current cardiology practice. Future research, including large outcome trials, is much awaited. Yet, adequate diagnosis is possible and treatment options are available and vital to reduce symptoms and most probably improve cardiovascular prognosis. This review intends to give a brief overview of the clinical presentation, underlying pathophysiology, and the diagnostic and treatment options in patients with suspected INOCA.

Original language	English
Pages (from-to)	66-72
Number of pages	7
Journal	Netherlands heart journal
Volume	28
DOIs	https://doi.org/10.1007/s12471-020-01451-9
Publication status	Published - 1 Aug 2020

Keywords

Coronary vascular dysfunction
Coronary vasospasm
Gender
INOCA
Microvascular angina

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https://doi.org/10.1007/s12471-020-01451-9

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title = "Ischaemia with no obstructive coronary arteries",

abstract = "Ischaemia with no obstructive coronary arteries (INOCA) is a common ischaemic heart disease with a female preponderance, mostly due to underlying coronary vascular dysfunction comprising coronary microvascular dysfunction and/or epicardial coronary vasospasm. Since standard ischaemia detection tests and coronary angiograms are not suitable to diagnose coronary vascular dysfunction, INOCA is often overlooked in current cardiology practice. Future research, including large outcome trials, is much awaited. Yet, adequate diagnosis is possible and treatment options are available and vital to reduce symptoms and most probably improve cardiovascular prognosis. This review intends to give a brief overview of the clinical presentation, underlying pathophysiology, and the diagnostic and treatment options in patients with suspected INOCA.",

keywords = "Coronary vascular dysfunction, Coronary vasospasm, Gender, INOCA, Microvascular angina",

author = "Konst, {R. E.} and Meeder, {J. G.} and Wittekoek, {M. E.} and Maas, {A. H.E.M.} and Y. Appelman and Piek, {J. J.} and {van de Hoef}, {T. P.} and P. Damman and Elias-Smale, {S. E.}",

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AU - Konst, R. E.

AU - Meeder, J. G.

AU - Wittekoek, M. E.

AU - Maas, A. H.E.M.

AU - Appelman, Y.

AU - Piek, J. J.

AU - van de Hoef, T. P.

AU - Damman, P.

AU - Elias-Smale, S. E.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Ischaemia with no obstructive coronary arteries (INOCA) is a common ischaemic heart disease with a female preponderance, mostly due to underlying coronary vascular dysfunction comprising coronary microvascular dysfunction and/or epicardial coronary vasospasm. Since standard ischaemia detection tests and coronary angiograms are not suitable to diagnose coronary vascular dysfunction, INOCA is often overlooked in current cardiology practice. Future research, including large outcome trials, is much awaited. Yet, adequate diagnosis is possible and treatment options are available and vital to reduce symptoms and most probably improve cardiovascular prognosis. This review intends to give a brief overview of the clinical presentation, underlying pathophysiology, and the diagnostic and treatment options in patients with suspected INOCA.

AB - Ischaemia with no obstructive coronary arteries (INOCA) is a common ischaemic heart disease with a female preponderance, mostly due to underlying coronary vascular dysfunction comprising coronary microvascular dysfunction and/or epicardial coronary vasospasm. Since standard ischaemia detection tests and coronary angiograms are not suitable to diagnose coronary vascular dysfunction, INOCA is often overlooked in current cardiology practice. Future research, including large outcome trials, is much awaited. Yet, adequate diagnosis is possible and treatment options are available and vital to reduce symptoms and most probably improve cardiovascular prognosis. This review intends to give a brief overview of the clinical presentation, underlying pathophysiology, and the diagnostic and treatment options in patients with suspected INOCA.

KW - Coronary vascular dysfunction

KW - Coronary vasospasm

KW - Gender

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KW - Microvascular angina

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JO - Netherlands heart journal

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ER -

Ischaemia with no obstructive coronary arteries

Abstract

Keywords

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