TY - JOUR
T1 - Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors
AU - Schiemanck, S.K.
AU - Post, M.W.
AU - Kwakkel, G.
AU - Witkamp, T.D.
AU - Kappelle, L.J.
AU - Prevo, A.J.
PY - 2005/8/23
Y1 - 2005/8/23
N2 - Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.
AB - Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): -0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): -0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (rs = 0.30; p < 0.01), modified Rankin Scale (rs = 0.39; p < 0.01) and Frenchay Activities Index (rs = -0.35; p < 0.01). Lesion volume had a significant but low association (rs = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; rs = -0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke.
KW - Infarction
KW - Lesion volume
KW - Magnetic resonance imaging
KW - Middle cerebral artery
KW - Outcome
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=23644462849&partnerID=8YFLogxK
M3 - Article
C2 - 16082082
SN - 0922-6028
VL - 23
SP - 257
EP - 263
JO - Restorative neurology and neuroscience
JF - Restorative neurology and neuroscience
IS - 3-4
ER -