TY - JOUR
T1 - Kidney and liver fat accumulation
T2 - from imaging to clinical consequences
AU - Yıldız, Abdullah B.
AU - Vehbi, Sezan
AU - Copur, Sidar
AU - Gurses, Bengi
AU - Siriopol, Dimitrie
AU - Karakaya, Bahar Afak Durur
AU - Hasbal, Nuri B.
AU - Tekin, Bahar
AU - Akyıldız, Murat
AU - van Raalte, Daniel H.
AU - Cozzolino, Mario
AU - Kanbay, Mehmet
N1 - Funding Information: This study was not funded by any grant. Publisher Copyright: © 2023, The Author(s) under exclusive licence to Italian Society of Nephrology.
PY - 2023
Y1 - 2023
N2 - Background: Recent studies indicate that accumulation of adipose tissue in various organs such as liver and kidney may contribute to the pathophysiology of metabolic syndrome. We aim to investigate the association between kidney and liver adipose tissue accumulation, assessed by the magnetic resonance imaging (MRI) proton density fat fraction technique, along with its relation to clinical and biochemical parameters. Methods: We included 51 volunteers with phenotypical features of metabolic syndrome (mean age = 34 years, mean body-mass index = 26.4 kg/m 2) in our study in which liver and kidney adipose tissue accumulation was assessed via MRI-proton density fat fraction along with multiple other clinical and biochemical parameters such as estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio, serum lipid profile, liver function tests and body-mass index (BMI). Results: Our results from the univariate linear regression analysis indicate that both the kidney and liver scores were positively correlated with markers such as BMI, urine albumin-to-creatinine ratio, triglycerides (p < 0.001) and negatively correlated with eGFR (p < 0.05). In multivariate analysis, urine albumin-to-creatinine ratio (p < 0.05), triglycerides (p < 0.01), eGFR (p < 0.05) and BMI (p < 0.001) were found to be independently associated with kidney and liver fat accumulation, respectively (R 2 = 0.64; R 2 = 0.89). There was also a positive correlation between kidney and liver fat accumulation. Conclusion: We have found a significant association between adipose tissue accumulation in liver and kidney and the parameters of metabolic syndrome. Moreover, the presence of a strong association between kidney and liver fat accumulation and kidney function parameters such as urine albumin-to-creatinine ratio and eGFR may be an indicator of the clinical significance of parenchymal fat accumulation. Graphical abstract: [Figure not available: see fulltext.].
AB - Background: Recent studies indicate that accumulation of adipose tissue in various organs such as liver and kidney may contribute to the pathophysiology of metabolic syndrome. We aim to investigate the association between kidney and liver adipose tissue accumulation, assessed by the magnetic resonance imaging (MRI) proton density fat fraction technique, along with its relation to clinical and biochemical parameters. Methods: We included 51 volunteers with phenotypical features of metabolic syndrome (mean age = 34 years, mean body-mass index = 26.4 kg/m 2) in our study in which liver and kidney adipose tissue accumulation was assessed via MRI-proton density fat fraction along with multiple other clinical and biochemical parameters such as estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio, serum lipid profile, liver function tests and body-mass index (BMI). Results: Our results from the univariate linear regression analysis indicate that both the kidney and liver scores were positively correlated with markers such as BMI, urine albumin-to-creatinine ratio, triglycerides (p < 0.001) and negatively correlated with eGFR (p < 0.05). In multivariate analysis, urine albumin-to-creatinine ratio (p < 0.05), triglycerides (p < 0.01), eGFR (p < 0.05) and BMI (p < 0.001) were found to be independently associated with kidney and liver fat accumulation, respectively (R 2 = 0.64; R 2 = 0.89). There was also a positive correlation between kidney and liver fat accumulation. Conclusion: We have found a significant association between adipose tissue accumulation in liver and kidney and the parameters of metabolic syndrome. Moreover, the presence of a strong association between kidney and liver fat accumulation and kidney function parameters such as urine albumin-to-creatinine ratio and eGFR may be an indicator of the clinical significance of parenchymal fat accumulation. Graphical abstract: [Figure not available: see fulltext.].
KW - Kidney fat
KW - Liver steatosis
KW - MRI-PDFF
KW - Metabolic syndrome
KW - Urine albumin-to-creatinine ratio
UR - http://www.scopus.com/inward/record.url?scp=85180202639&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s40620-023-01824-4
DO - https://doi.org/10.1007/s40620-023-01824-4
M3 - Article
C2 - 38133740
SN - 1121-8428
JO - Journal of nephrology
JF - Journal of nephrology
ER -