TY - JOUR
T1 - Kidney Function and the Risk of Stroke and Dementia
T2 - The Rotterdam Study
AU - Koop-Nieuwelink, Carolien
AU - Sedaghat, Sanaz
AU - Mutlu, Unal
AU - Licher, Silvan
AU - Franco, Oscar H.
AU - Ikram, M. Arfan
AU - Geerlings, Mirjam I.
AU - Ikram, M. Kamran
AU - Bos, Daniel
PY - 2019
Y1 - 2019
N2 - Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.
AB - Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061752202&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30664508
U2 - https://doi.org/10.3233/JAD-181086
DO - https://doi.org/10.3233/JAD-181086
M3 - Article
C2 - 30664508
SN - 1387-2877
VL - 67
SP - 821
EP - 826
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -