Lack of association between VEGF polymorphisms and ALS in a Dutch population

P. W. J. van Vught; N. A. Sutedja; J. H. Veldink; B. P. C. Koeleman; G. J. Groeneveld; C. Wijmenga; B. M. J. Uitdehaag; J. M. B. V. de Jong; F. Baas; J. H. J. Wokke; L. H. van den Berg

doi:https://doi.org/10.1212/01.wnl.0000184514.39853.56

Lack of association between VEGF polymorphisms and ALS in a Dutch population

P. W. J. van Vught, N. A. Sutedja, J. H. Veldink, B. P. C. Koeleman, G. J. Groeneveld, C. Wijmenga, B. M. J. Uitdehaag, J. M. B. V. de Jong, F. Baas, J. H. J. Wokke, L. H. van den Berg

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Abstract

Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype

Original language	English
Pages (from-to)	1643-1645
Journal	Neurology
Volume	65
Issue number	10
DOIs	https://doi.org/10.1212/01.wnl.0000184514.39853.56
Publication status	Published - 2005

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https://doi.org/10.1212/01.wnl.0000184514.39853.56

Cite this

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title = "Lack of association between VEGF polymorphisms and ALS in a Dutch population",

abstract = "Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype",

author = "{van Vught}, {P. W. J.} and Sutedja, {N. A.} and Veldink, {J. H.} and Koeleman, {B. P. C.} and Groeneveld, {G. J.} and C. Wijmenga and Uitdehaag, {B. M. J.} and {de Jong}, {J. M. B. V.} and F. Baas and Wokke, {J. H. J.} and {van den Berg}, {L. H.}",

year = "2005",

doi = "https://doi.org/10.1212/01.wnl.0000184514.39853.56",

language = "English",

volume = "65",

pages = "1643--1645",

journal = "Neurology",

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publisher = "American Academy of Neurology",

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TY - JOUR

T1 - Lack of association between VEGF polymorphisms and ALS in a Dutch population

AU - van Vught, P. W. J.

AU - Sutedja, N. A.

AU - Veldink, J. H.

AU - Koeleman, B. P. C.

AU - Groeneveld, G. J.

AU - Wijmenga, C.

AU - Uitdehaag, B. M. J.

AU - de Jong, J. M. B. V.

AU - Baas, F.

AU - Wokke, J. H. J.

AU - van den Berg, L. H.

PY - 2005

Y1 - 2005

N2 - Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype

AB - Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype

U2 - https://doi.org/10.1212/01.wnl.0000184514.39853.56

DO - https://doi.org/10.1212/01.wnl.0000184514.39853.56

M3 - Article

C2 - 16301496

SN - 0028-3878

VL - 65

SP - 1643

EP - 1645

JO - Neurology

JF - Neurology

IS - 10

ER -