Langerin functions as an antiviral receptor on Langerhans cells

Michiel van der Vlist; Teunis B. H. Geijtenbeek

doi:https://doi.org/10.1038/icb.2010.32

Langerin functions as an antiviral receptor on Langerhans cells

Michiel van der Vlist, Teunis B. H. Geijtenbeek

Research output: Contribution to journal › Review article › Academic › peer-review

64 Citations (Scopus)

Abstract

Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In addition, antigens targeted to Langerin are presented to T cells to induce an adaptive immune response. Therefore Langerin functions as an innate anti-viral defense mechanism and an antigen receptor involved in adaptive immune responses. Here, we review the role of Langerin in antiviral protection, its structural similarity to other C-type lectins, and how its function and polymorphisms influence the function of Langerhans cells. Immunology and Cell Biology (2010) 88, 410-415; doi: 10.1038/icb.2010.32; published online 23 March 2010

Original language	English
Pages (from-to)	410-415
Journal	Immunology and Cell Biology
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/icb.2010.32
Publication status	Published - 2010

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https://doi.org/10.1038/icb.2010.32

Cite this

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title = "Langerin functions as an antiviral receptor on Langerhans cells",

abstract = "Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In addition, antigens targeted to Langerin are presented to T cells to induce an adaptive immune response. Therefore Langerin functions as an innate anti-viral defense mechanism and an antigen receptor involved in adaptive immune responses. Here, we review the role of Langerin in antiviral protection, its structural similarity to other C-type lectins, and how its function and polymorphisms influence the function of Langerhans cells. Immunology and Cell Biology (2010) 88, 410-415; doi: 10.1038/icb.2010.32; published online 23 March 2010",

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T1 - Langerin functions as an antiviral receptor on Langerhans cells

AU - van der Vlist, Michiel

AU - Geijtenbeek, Teunis B. H.

PY - 2010

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N2 - Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In addition, antigens targeted to Langerin are presented to T cells to induce an adaptive immune response. Therefore Langerin functions as an innate anti-viral defense mechanism and an antigen receptor involved in adaptive immune responses. Here, we review the role of Langerin in antiviral protection, its structural similarity to other C-type lectins, and how its function and polymorphisms influence the function of Langerhans cells. Immunology and Cell Biology (2010) 88, 410-415; doi: 10.1038/icb.2010.32; published online 23 March 2010

AB - Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In addition, antigens targeted to Langerin are presented to T cells to induce an adaptive immune response. Therefore Langerin functions as an innate anti-viral defense mechanism and an antigen receptor involved in adaptive immune responses. Here, we review the role of Langerin in antiviral protection, its structural similarity to other C-type lectins, and how its function and polymorphisms influence the function of Langerhans cells. Immunology and Cell Biology (2010) 88, 410-415; doi: 10.1038/icb.2010.32; published online 23 March 2010

U2 - https://doi.org/10.1038/icb.2010.32

DO - https://doi.org/10.1038/icb.2010.32

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