TY - JOUR
T1 - Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
AU - BBMRI Metabolomics Consortium
AU - Onderwater, Gerrit L.J.
AU - Ligthart, Lannie
AU - Bot, Mariska
AU - Demirkan, Ayse
AU - Fu, Jingyuan
AU - van der Kallen, Carla J.H.
AU - Vijfhuizen, Lisanne S.
AU - Pool, René
AU - Liu, Jun
AU - Vanmolkot, Floris H.M.
AU - Beekman, Marian
AU - Wen, Ke Xin
AU - Amin, Najaf
AU - Thesing, Carisha S.
AU - Pijpers, Judith A.
AU - Kies, Dennis A.
AU - Zielman, Ronald
AU - de Boer, Irene
AU - van Greevenbroek, Marleen M.J.
AU - Arts, Ilja C.W.
AU - Milaneschi, Yuri
AU - Schram, Miranda T.
AU - Dagnelie, Pieter C.
AU - Franke, Lude
AU - Ikram, M. Arfan
AU - Ferrari, Michel D.
AU - Goeman, Jelle J.
AU - Slagboom, P. Eline
AU - Wijmenga, Cisca
AU - Stehouwer, Coen D.A.
AU - Boomsma, Dorret I.
AU - van Duijn, Cornelia M.
AU - Penninx, Brenda W.
AU - 't Hoen, Peter A.C.
AU - Terwindt, Gisela M.
AU - van den Maagdenberg, Arn M.J.M.
N1 - Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
PY - 2019/4/16
Y1 - 2019/4/16
N2 - OBJECTIVE: To identify a plasma metabolomic biomarker signature for migraine.METHODS: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses.RESULTS: Decreases in the level of apolipoprotein A1 (β -0.10; 95% confidence interval [CI] -0.16, -0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β -0.10; 95% CI -0.15, -0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β -0.24; 95% CI -0.36, -0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status.CONCLUSIONS: Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs.
AB - OBJECTIVE: To identify a plasma metabolomic biomarker signature for migraine.METHODS: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses.RESULTS: Decreases in the level of apolipoprotein A1 (β -0.10; 95% confidence interval [CI] -0.16, -0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β -0.10; 95% CI -0.15, -0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β -0.24; 95% CI -0.36, -0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status.CONCLUSIONS: Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs.
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U2 - https://doi.org/10.1212/WNL.0000000000007313
DO - https://doi.org/10.1212/WNL.0000000000007313
M3 - Article
C2 - 30944236
SN - 0028-3878
VL - 92
SP - e1899-e1911
JO - Neurology
JF - Neurology
IS - 16
ER -
