TY - JOUR
T1 - Late Complications in Long-Term Childhood Cancer Survivors
T2 - What the Oral Health Professional Needs to Know
AU - Al-Ansari, Sali
AU - Stolze, Juliette
AU - Bresters, Dorine
AU - Brook, Alan Henry
AU - Laheij, Alexa M.G.A.
AU - Brand, Henk S.
AU - Dahllöf, Göran
AU - Rozema, Frederik R.
AU - Raber-Durlacher, Judith E.
N1 - Publisher Copyright: © 2024 by the authors.
PY - 2024/1
Y1 - 2024/1
N2 - With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from damage caused by their cancer treatment to endocrine, cardiovascular, musculoskeletal, and other organ systems. These complications may surface decades after the completion of treatment. Adverse outcomes of childhood cancer treatment frequently involve oral and craniofacial structures including the dentition. Tooth development, salivary gland function, craniofacial growth, and temporomandibular joint function may be disturbed, increasing oral health risks in these individuals. Moreover, CCS are at risk of developing subsequent malignancies, which may manifest in or near the oral cavity. It is important that dental practitioners are aware of the childhood cancer history of their patients and have knowledge of potential late complications. Therefore, this narrative review aims to inform dental practitioners of late oral complications of cancer treatment modalities commonly used in pediatric oncology. Furthermore, selected common non-oral late sequelae of cancer therapy that could have an impact on oral health and on delivering dental care will be discussed.
AB - With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from damage caused by their cancer treatment to endocrine, cardiovascular, musculoskeletal, and other organ systems. These complications may surface decades after the completion of treatment. Adverse outcomes of childhood cancer treatment frequently involve oral and craniofacial structures including the dentition. Tooth development, salivary gland function, craniofacial growth, and temporomandibular joint function may be disturbed, increasing oral health risks in these individuals. Moreover, CCS are at risk of developing subsequent malignancies, which may manifest in or near the oral cavity. It is important that dental practitioners are aware of the childhood cancer history of their patients and have knowledge of potential late complications. Therefore, this narrative review aims to inform dental practitioners of late oral complications of cancer treatment modalities commonly used in pediatric oncology. Furthermore, selected common non-oral late sequelae of cancer therapy that could have an impact on oral health and on delivering dental care will be discussed.
KW - childhood cancer survivors
KW - chronic oral complications
KW - dental treatment
KW - hyposalivation
KW - late effects
KW - oral care
KW - pediatric cancer
KW - xerostomia
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U2 - https://doi.org/10.3390/dj12010017
DO - https://doi.org/10.3390/dj12010017
M3 - Review article
SN - 2304-6767
VL - 12
SP - 1
EP - 17
JO - Dentistry Journal
JF - Dentistry Journal
IS - 1
M1 - 17
ER -