TY - JOUR
T1 - LDL-C/HDL-C ratio in subjects with cardiovascular disease and a low HDL-C: results of the RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport) study
AU - Jukema, J. Wouter
AU - Liem, An-Ho
AU - Dunselman, Peter H. J. M.
AU - van der Sloot, Jos A. P.
AU - Lok, Dirk J. A.
AU - Zwinderman, Aeilko H.
PY - 2005
Y1 - 2005
N2 - Background: The ratio of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (LDL-C/HDL-C) is a reliable predictor of cardiovascular risk. Low HDL-C levels in patients with coronary artery disease are associated with a high risk for cardiovascular events. Objectives: This study compared the effects of rosuvastatin and atorvastatin on the LDL-C/HDL-C ratio in patients with cardiovascular disease and low HDL-C. Methods: Patients aged 40-80 years with established cardiovascular disease and HDL-C <1.0 mmol/L ( <40 mg/dL) entered a 6-week dietary run-in period, before randomisation to open-label treatment with rosuvastatin 10 mg (n = 230) or atorvastatin 20 mg (n = 231) for 6 weeks. Doses were increased after 6 weeks to rosuvastatin 20 mg or atorvastatin 40 mg, and after 12 weeks to rosuvastatin 40 mg or atorvastatin 80 mg. Serum lipid parameters were measured at baseline and 6, 12 and 18 weeks. Results: After 6 weeks of treatment, mean percentage change from baseline in LDL-C/HDL-C ratio was -47.0% in the rosuvastatin group and -41.9% in the atorvastatin group (p <0.05 for between-group comparison). After 12 and 18 weeks of treatment, change from baseline was -53.0% and -57.3%, respectively, for rosuvastatin, compared with -47.9% and -49.6%, respectively, for atorvastatin (p <0.01 and p <0.001, respectively, for between-group comparison). Rosuvastatin also reduced LDL-C, total cholesterol and non-HDL-C significantly more than atorvastatin at all three time points, and significantly improved total cholesterol/HDL-C and apolipoprotein B/A-I ratios. Conclusions: Rosuvastatin 10, 20 and 40 mg is significantly more effective than atorvastatin 20, 40 and 80 mg, respectively, in improving the LDL-C/HDL-C ratio in patients with cardiovascular disease and low HDL-C. Further studies are required to clarify the benefits of rosuvastatin for reduction of cardiovascular risk
AB - Background: The ratio of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (LDL-C/HDL-C) is a reliable predictor of cardiovascular risk. Low HDL-C levels in patients with coronary artery disease are associated with a high risk for cardiovascular events. Objectives: This study compared the effects of rosuvastatin and atorvastatin on the LDL-C/HDL-C ratio in patients with cardiovascular disease and low HDL-C. Methods: Patients aged 40-80 years with established cardiovascular disease and HDL-C <1.0 mmol/L ( <40 mg/dL) entered a 6-week dietary run-in period, before randomisation to open-label treatment with rosuvastatin 10 mg (n = 230) or atorvastatin 20 mg (n = 231) for 6 weeks. Doses were increased after 6 weeks to rosuvastatin 20 mg or atorvastatin 40 mg, and after 12 weeks to rosuvastatin 40 mg or atorvastatin 80 mg. Serum lipid parameters were measured at baseline and 6, 12 and 18 weeks. Results: After 6 weeks of treatment, mean percentage change from baseline in LDL-C/HDL-C ratio was -47.0% in the rosuvastatin group and -41.9% in the atorvastatin group (p <0.05 for between-group comparison). After 12 and 18 weeks of treatment, change from baseline was -53.0% and -57.3%, respectively, for rosuvastatin, compared with -47.9% and -49.6%, respectively, for atorvastatin (p <0.01 and p <0.001, respectively, for between-group comparison). Rosuvastatin also reduced LDL-C, total cholesterol and non-HDL-C significantly more than atorvastatin at all three time points, and significantly improved total cholesterol/HDL-C and apolipoprotein B/A-I ratios. Conclusions: Rosuvastatin 10, 20 and 40 mg is significantly more effective than atorvastatin 20, 40 and 80 mg, respectively, in improving the LDL-C/HDL-C ratio in patients with cardiovascular disease and low HDL-C. Further studies are required to clarify the benefits of rosuvastatin for reduction of cardiovascular risk
U2 - https://doi.org/10.1185/030079905X74952
DO - https://doi.org/10.1185/030079905X74952
M3 - Article
C2 - 16307708
SN - 0300-7995
VL - 21
SP - 1865
EP - 1874
JO - Current medical research and opinion
JF - Current medical research and opinion
IS - 11
ER -