TY - JOUR
T1 - Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure
T2 - the HaFaC cohort study
AU - Bouwmeester, Sjoerd
AU - van der Stam, Jonna A.
AU - van Loon, Saskia L.M.
AU - van Riel, Natal A.W.
AU - Boer, Arjen Kars
AU - Dekker, Lukas R.
AU - Scharnhorst, Volkher
AU - Houthuizen, Patrick
N1 - Publisher Copyright: © 2022. The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: The left atrium (LA) is a key player in the pathophysiology of systolic and diastolic heart failure (HF). Speckle tracking derived LA reservoir strain (LASr) can be used as a prognostic surrogate for elevated left ventricular filling pressure similar to NT-proBNP. The aim of the study is to investigate the correlation between LASr and NT-proBNP and its prognostic value with regards to the composite endpoint of HF hospitalization and all-cause mortality within 1 year. Methods: Outpatients, sent to the echocardiography core lab because of HF, were enrolled into this study. Patients underwent a transthoracic echocardiographic examination, commercially available software was used to measure LASr. Blood samples were collected directly after the echocardiographic examination to determine NT-proBNP. Results: We included 174 HF patients, 43% with reduced, 36% with mildly reduced, and 21% with preserved ejection fraction. The study population showed a strong inverse correlation between LASr and log-transformed NT-proBNP (r = − 0.75, p < 0.01). Compared to NT-proBNP, LASr predicts the endpoint with a comparable specificity (83% vs. 84%), however with a lower sensitivity (70% vs. 61%). Conclusion: LASr is inversely correlated with NT-proBNP and a good echocardiographic predictor for the composite endpoint of hospitalization and all-cause mortality in patients with HF. Trial registration:https://www.trialregister.nl/trial/7268
AB - Background: The left atrium (LA) is a key player in the pathophysiology of systolic and diastolic heart failure (HF). Speckle tracking derived LA reservoir strain (LASr) can be used as a prognostic surrogate for elevated left ventricular filling pressure similar to NT-proBNP. The aim of the study is to investigate the correlation between LASr and NT-proBNP and its prognostic value with regards to the composite endpoint of HF hospitalization and all-cause mortality within 1 year. Methods: Outpatients, sent to the echocardiography core lab because of HF, were enrolled into this study. Patients underwent a transthoracic echocardiographic examination, commercially available software was used to measure LASr. Blood samples were collected directly after the echocardiographic examination to determine NT-proBNP. Results: We included 174 HF patients, 43% with reduced, 36% with mildly reduced, and 21% with preserved ejection fraction. The study population showed a strong inverse correlation between LASr and log-transformed NT-proBNP (r = − 0.75, p < 0.01). Compared to NT-proBNP, LASr predicts the endpoint with a comparable specificity (83% vs. 84%), however with a lower sensitivity (70% vs. 61%). Conclusion: LASr is inversely correlated with NT-proBNP and a good echocardiographic predictor for the composite endpoint of hospitalization and all-cause mortality in patients with HF. Trial registration:https://www.trialregister.nl/trial/7268
KW - HFmrEF
KW - HFpEF
KW - HFrEF
KW - Left atrial strain
KW - NT-proBNP
UR - http://www.scopus.com/inward/record.url?scp=85126704851&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s12872-022-02545-5
DO - https://doi.org/10.1186/s12872-022-02545-5
M3 - Article
C2 - 35287575
SN - 1471-2261
VL - 22
SP - 104
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
IS - 1
M1 - 104
ER -