TY - JOUR
T1 - Left atrial sphericity in relation to atrial strain and strain rate in atrial fibrillation patients
AU - Hopman, Luuk H. G. A.
AU - Bhagirath, Pranav
AU - Mulder, Mark J.
AU - Demirkiran, Ahmet
AU - Mathari, Sulayman El
AU - van der Laan, Anja M.
AU - van Rossum, Albert C.
AU - Kemme, Michiel J. B.
AU - Allaart, Cornelis P.
AU - Götte, Marco J. W.
N1 - Funding Information: None. Publisher Copyright: © 2023, The Author(s).
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Purpose: Left atrial (LA) sphericity is a novel, geometry-based parameter that has been used to visualize and quantify LA geometrical remodeling in patients with atrial fibrillation (AF). This study examined the association between LA sphericity, and LA longitudinal strain and strain rate measured by feature-tracking in AF patients. Methods: 128 AF patients who underwent cardiovascular magnetic resonance (CMR) imaging in sinus rhythm prior to their pulmonary vein isolation (PVI) procedure were retrospectively analyzed. LA sphericity was calculated by segmenting the LA (excluding the pulmonary veins and the LA appendage) on a 3D contrast enhanced MR angiogram and comparing the resulting shape with a perfect sphere. LA global reservoir strain, conduit strain, contractile strain and corresponding strain rates were derived from cine images using feature-tracking. For statistical analysis, Pearson correlations, multivariable logistic regression analysis, and Student t-tests were used. Results: Patients with a spherical LA (dichotomized by the median value) had a lower reservoir strain and conduit strain compared to patients with a non-spherical LA (-15.4 ± 4.2% vs. -17.1 ± 3.5%, P = 0.02 and − 8.2 ± 3.0% vs. -9.5 ± 2.6%, P = 0.01, respectively). LA strain rate during early ventricular diastole was also different between both groups (-0.7 ± 0.3s− 1 vs. -0.9 ± 0.3s− 1, P = 0.001). In contrast, no difference was found for LA contractile strain (-7.2 ± 2.6% vs. -7.6 ± 2.2%, P = 0.30). Conclusions: LA passive strain is significantly impaired in AF patients with a spherical LA, though this relation was not independent from LA volume.
AB - Purpose: Left atrial (LA) sphericity is a novel, geometry-based parameter that has been used to visualize and quantify LA geometrical remodeling in patients with atrial fibrillation (AF). This study examined the association between LA sphericity, and LA longitudinal strain and strain rate measured by feature-tracking in AF patients. Methods: 128 AF patients who underwent cardiovascular magnetic resonance (CMR) imaging in sinus rhythm prior to their pulmonary vein isolation (PVI) procedure were retrospectively analyzed. LA sphericity was calculated by segmenting the LA (excluding the pulmonary veins and the LA appendage) on a 3D contrast enhanced MR angiogram and comparing the resulting shape with a perfect sphere. LA global reservoir strain, conduit strain, contractile strain and corresponding strain rates were derived from cine images using feature-tracking. For statistical analysis, Pearson correlations, multivariable logistic regression analysis, and Student t-tests were used. Results: Patients with a spherical LA (dichotomized by the median value) had a lower reservoir strain and conduit strain compared to patients with a non-spherical LA (-15.4 ± 4.2% vs. -17.1 ± 3.5%, P = 0.02 and − 8.2 ± 3.0% vs. -9.5 ± 2.6%, P = 0.01, respectively). LA strain rate during early ventricular diastole was also different between both groups (-0.7 ± 0.3s− 1 vs. -0.9 ± 0.3s− 1, P = 0.001). In contrast, no difference was found for LA contractile strain (-7.2 ± 2.6% vs. -7.6 ± 2.2%, P = 0.30). Conclusions: LA passive strain is significantly impaired in AF patients with a spherical LA, though this relation was not independent from LA volume.
KW - Atrial fibrillation
KW - Atrial remodeling
KW - Atrial sphericity
KW - Atrial strain
KW - Cardiac MRI
UR - http://www.scopus.com/inward/record.url?scp=85172827724&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10554-023-02866-2
DO - https://doi.org/10.1007/s10554-023-02866-2
M3 - Article
C2 - 37515682
SN - 1569-5794
VL - 39
SP - 1753
EP - 1763
JO - international journal of cardiovascular imaging
JF - international journal of cardiovascular imaging
IS - 9
ER -