TY - JOUR
T1 - Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
AU - Warmink-Perdijk, Willemijn D. B.
AU - Peters, Lilian L.
AU - Tigchelaar, Ettje F.
AU - Dekens, Jackie A. M.
AU - Jankipersadsing, Soesma A.
AU - Zhernakova, Alexandra
AU - Bossers, Willem J. R.
AU - Sikkema, Jan
AU - de Jonge, Ank
AU - Reijneveld, Sijmen A.
AU - Verkade, Henkjan J.
AU - Koppelman, Gerard H.
AU - Wijmenga, Cisca
AU - Kuipers, Folkert
AU - Scherjon, Sicco A.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
AB - Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials-including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine-will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
KW - Biobank
KW - Birth cohort
KW - Developmental Origins of Health and Disease (DOHaD)
KW - Microbiome
KW - Prospective study
KW - Transgenerational effects
UR - http://www.scopus.com/inward/record.url?scp=85083003394&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10654-020-00614-7
DO - https://doi.org/10.1007/s10654-020-00614-7
M3 - Article
C2 - 32100173
SN - 0393-2990
VL - 35
SP - 157
EP - 168
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 2
ER -