Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies

Rosa Vissenberg; Eric Fliers; Joris A. M. van der Post; Madelon van Wely; Peter H. Bisschop; Mariette Goddijn

doi:https://doi.org/10.3109/09513590.2015.1092513

Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies

Rosa Vissenberg, Eric Fliers, Joris A. M. van der Post, Madelon van Wely, Peter H. Bisschop, Mariette Goddijn

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine

Original language	English
Pages (from-to)	132-135
Journal	Gynecological endocrinology
Volume	32
Issue number	2
DOIs	https://doi.org/10.3109/09513590.2015.1092513
Publication status	Published - 2016

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https://doi.org/10.3109/09513590.2015.1092513

Cite this

@article{24811b45d2964229a538a99f4121a4d8,

title = "Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies",

abstract = "Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine",

author = "Rosa Vissenberg and Eric Fliers and {van der Post}, {Joris A. M.} and {van Wely}, Madelon and Bisschop, {Peter H.} and Mariette Goddijn",

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T1 - Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies

AU - Vissenberg, Rosa

AU - Fliers, Eric

AU - van der Post, Joris A. M.

AU - van Wely, Madelon

AU - Bisschop, Peter H.

AU - Goddijn, Mariette

PY - 2016

Y1 - 2016

N2 - Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine

AB - Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine

U2 - https://doi.org/10.3109/09513590.2015.1092513

DO - https://doi.org/10.3109/09513590.2015.1092513

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