TY - JOUR
T1 - Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies
AU - Vissenberg, Rosa
AU - Fliers, Eric
AU - van der Post, Joris A. M.
AU - van Wely, Madelon
AU - Bisschop, Peter H.
AU - Goddijn, Mariette
PY - 2016
Y1 - 2016
N2 - Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine
AB - Thyroid autoimmunity with normal thyroid function is associated with recurrent miscarriage (RM), but the association with live birth is less clear. Therefore, we determined the association between thyroid peroxidase antibodies (TPO-Ab) and live-birth rate (LBR) in a retrospective cohort of euthyroid women with unexplained RM. We included 202 women of which 28 were TPO-Ab positive (13.9%) and 174 were TPO-Ab negative. TPO-Ab positive women (n = 10) without levothyroxine treatment had a lower LBR (29%) compared to TPO-Ab negative women (51%) (HR 0.23, 0.07-0.72, p = 0.012). The LBR in women with TPO-Ab receiving levothyroxine was not different compared women without TPO-Ab (60% versus 51%, p = 0.50). In conclusion, TPO-Ab are associated with a lower LBR in euthyroid women with unexplained RM and these women may benefit from treatment with levothyroxine
U2 - https://doi.org/10.3109/09513590.2015.1092513
DO - https://doi.org/10.3109/09513590.2015.1092513
M3 - Article
C2 - 26430806
SN - 0951-3590
VL - 32
SP - 132
EP - 135
JO - Gynecological endocrinology
JF - Gynecological endocrinology
IS - 2
ER -