Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse

V. Daeichin; J. C. Sluimer; K. van der Heiden; I. Skachkov; K. Kooiman; A. Janssen; B. Janssen; J. G. Bosch; N. de Jong; M. J. A. P. Daemen; A. F. W. van der Steen

doi:https://doi.org/10.1055/s-0035-1565092

Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse

V. Daeichin, J. C. Sluimer, K. van der Heiden, I. Skachkov, K. Kooiman, A. Janssen, B. Janssen, J. G. Bosch, N. de Jong, M. J. A. P. Daemen, A. F. W. van der Steen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE(-/-) mouse. During live contrast-enhanced ultrasonography of a 50-week-old ApoE(-/-) male mouse, symptoms suggesting plaque disruption in the brachiocephalic artery were observed. Histological analysis confirmed the presence of advanced atherosclerotic lesions with dissections and intraplaque hemorrhage in the affected brachiocephalic trunk, pointing towards plaque rupture as the cause of the observed event. However, we did not detect a luminal thrombus or cap rupture, which is a key criterion for plaque rupture in human atherosclerosis. This study reports the real-time occurrence of a possible plaque rupture in a living ApoE(-/-) mouse

Original language	English
Pages (from-to)	E67-E71
Journal	Ultrasound international open
Volume	1
Issue number	2
DOIs	https://doi.org/10.1055/s-0035-1565092
Publication status	Published - 2015

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https://doi.org/10.1055/s-0035-1565092

Cite this

@article{7baa58fa8dbe4512b1474df59cc48341,

title = "Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse",

abstract = "The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE(-/-) mouse. During live contrast-enhanced ultrasonography of a 50-week-old ApoE(-/-) male mouse, symptoms suggesting plaque disruption in the brachiocephalic artery were observed. Histological analysis confirmed the presence of advanced atherosclerotic lesions with dissections and intraplaque hemorrhage in the affected brachiocephalic trunk, pointing towards plaque rupture as the cause of the observed event. However, we did not detect a luminal thrombus or cap rupture, which is a key criterion for plaque rupture in human atherosclerosis. This study reports the real-time occurrence of a possible plaque rupture in a living ApoE(-/-) mouse",

author = "V. Daeichin and Sluimer, {J. C.} and {van der Heiden}, K. and I. Skachkov and K. Kooiman and A. Janssen and B. Janssen and Bosch, {J. G.} and {de Jong}, N. and Daemen, {M. J. A. P.} and {van der Steen}, {A. F. W.}",

year = "2015",

doi = "https://doi.org/10.1055/s-0035-1565092",

language = "English",

volume = "1",

pages = "E67--E71",

journal = "Ultrasound international open",

issn = "2509-596X",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse

AU - Daeichin, V.

AU - Sluimer, J. C.

AU - van der Heiden, K.

AU - Skachkov, I.

AU - Kooiman, K.

AU - Janssen, A.

AU - Janssen, B.

AU - Bosch, J. G.

AU - de Jong, N.

AU - Daemen, M. J. A. P.

AU - van der Steen, A. F. W.

PY - 2015

Y1 - 2015

N2 - The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE(-/-) mouse. During live contrast-enhanced ultrasonography of a 50-week-old ApoE(-/-) male mouse, symptoms suggesting plaque disruption in the brachiocephalic artery were observed. Histological analysis confirmed the presence of advanced atherosclerotic lesions with dissections and intraplaque hemorrhage in the affected brachiocephalic trunk, pointing towards plaque rupture as the cause of the observed event. However, we did not detect a luminal thrombus or cap rupture, which is a key criterion for plaque rupture in human atherosclerosis. This study reports the real-time occurrence of a possible plaque rupture in a living ApoE(-/-) mouse

AB - The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE(-/-) mouse. During live contrast-enhanced ultrasonography of a 50-week-old ApoE(-/-) male mouse, symptoms suggesting plaque disruption in the brachiocephalic artery were observed. Histological analysis confirmed the presence of advanced atherosclerotic lesions with dissections and intraplaque hemorrhage in the affected brachiocephalic trunk, pointing towards plaque rupture as the cause of the observed event. However, we did not detect a luminal thrombus or cap rupture, which is a key criterion for plaque rupture in human atherosclerosis. This study reports the real-time occurrence of a possible plaque rupture in a living ApoE(-/-) mouse

U2 - https://doi.org/10.1055/s-0035-1565092

DO - https://doi.org/10.1055/s-0035-1565092

M3 - Article

C2 - 27689156

SN - 2509-596X

VL - 1

SP - E67-E71

JO - Ultrasound international open

JF - Ultrasound international open

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