TY - JOUR
T1 - Local and travel-associated transmission of tuberculosis at Central Western border of Brazil, 2014–2017
AU - Walter, Katharine S.
AU - Tatara, Mariana Bento
AU - da Silva, Kesia Esther
AU - Moreira, Flora Martinez Figueira
AU - dos Santos, Paulo Cesar Pereira
AU - de Melo Ferrari, D. ndrea Driely
AU - Cunha, Eunice Atsuko
AU - Andrews, Jason R.
AU - Croda, Julio
N1 - Publisher Copyright: © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at international borders. We conducted prospective population-based genomic surveillance in 3 cities along Brazil’s central western border from 2014–2017. Although most isolates (89/132; 67%) fell within genomic transmission clusters, genetically unique isolates disproportionately occurred among participants with recent international travel (17/42; 40.5%), suggesting that both local transmission and migration contribute to incident TB. Isolates from 40 participants with and 76 without an incarceration history clustered together throughout a maximum-likelihood phylogeny, indicating the close interrelatedness of prison and community epidemics. Our findings highlight the need for ongoing surveillance to control continued introductions of TB and reduce the disproportionate burden of TB in prisons at Brazil’s international borders.
AB - International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at international borders. We conducted prospective population-based genomic surveillance in 3 cities along Brazil’s central western border from 2014–2017. Although most isolates (89/132; 67%) fell within genomic transmission clusters, genetically unique isolates disproportionately occurred among participants with recent international travel (17/42; 40.5%), suggesting that both local transmission and migration contribute to incident TB. Isolates from 40 participants with and 76 without an incarceration history clustered together throughout a maximum-likelihood phylogeny, indicating the close interrelatedness of prison and community epidemics. Our findings highlight the need for ongoing surveillance to control continued introductions of TB and reduce the disproportionate burden of TB in prisons at Brazil’s international borders.
UR - http://www.scopus.com/inward/record.url?scp=85101495934&partnerID=8YFLogxK
U2 - https://doi.org/10.3201/eid2703.203839
DO - https://doi.org/10.3201/eid2703.203839
M3 - Review article
C2 - 33622493
SN - 1080-6040
VL - 27
SP - 905
EP - 914
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 3
ER -