TY - JOUR
T1 - Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment
AU - Fransen, Marieke F.
AU - Arens, Ramon
AU - Melief, Cornelis J. M.
PY - 2013
Y1 - 2013
N2 - In recent years, it has become apparent that immunoregulatory processes influence cancer development. The key players in tumor progression are mainly present in the microenvironment of the tumor and the draining lymph nodes. Interventions aimed at shifting tumor-promoting actions toward effective tumor-eradicating immunity are thus foremost required locally. As immune-modulating therapy has been shown to cause many adverse side effects when administered systemically, we strongly advocate the further development of local treatment for cancer immunotherapy. Copyright © 2012 UICC.
AB - In recent years, it has become apparent that immunoregulatory processes influence cancer development. The key players in tumor progression are mainly present in the microenvironment of the tumor and the draining lymph nodes. Interventions aimed at shifting tumor-promoting actions toward effective tumor-eradicating immunity are thus foremost required locally. As immune-modulating therapy has been shown to cause many adverse side effects when administered systemically, we strongly advocate the further development of local treatment for cancer immunotherapy. Copyright © 2012 UICC.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84874118594&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22858832
U2 - https://doi.org/10.1002/ijc.27755
DO - https://doi.org/10.1002/ijc.27755
M3 - Review article
C2 - 22858832
SN - 0020-7136
VL - 132
SP - 1971
EP - 1976
JO - International journal of cancer
JF - International journal of cancer
IS - 9
ER -