Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment

Marieke F. Fransen, Ramon Arens, Cornelis J. M. Melief

Research output: Contribution to journalReview articleAcademicpeer-review

62 Citations (Scopus)


In recent years, it has become apparent that immunoregulatory processes influence cancer development. The key players in tumor progression are mainly present in the microenvironment of the tumor and the draining lymph nodes. Interventions aimed at shifting tumor-promoting actions toward effective tumor-eradicating immunity are thus foremost required locally. As immune-modulating therapy has been shown to cause many adverse side effects when administered systemically, we strongly advocate the further development of local treatment for cancer immunotherapy. Copyright © 2012 UICC.
Original languageEnglish
Pages (from-to)1971-1976
JournalInternational journal of cancer
Issue number9
Publication statusPublished - 2013
Externally publishedYes

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