Abstract
This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.
Original language | English |
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Pages (from-to) | 152-3 |
Number of pages | 2 |
Journal | Journal of clinical pathology |
Volume | 55 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2002 |
Keywords
- C-Reactive Protein
- Case Reports
- Fatal Outcome
- Female
- Humans
- Infarction
- Journal Article
- Kidney
- Liver
- Middle Aged
- Research Support, Non-U.S. Gov't
- Sepsis